DegronMD

Uniprot ID: O60641

Source protein: Clathrin coat assembly protein AP180

Source gene: SNAP91

Class: DEG_SCF_FBW7_1

Location: 406:413

E3 ligase: FBXW7

DEGRON score: 0.9988

ASA_SCORE: 86.75

COIL: 0.9559

CONS_SCORE: 0.2565

DSS_SCORE: 0.6861

HELIX: 0.0248

FCONS_SCORE: 1.0796

RIG_SCORE: 0.6365

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P403A	TCGA-85-A4JB	LUSC	TCGA	PEPTPPTT	DEG_SCF_FBW7_1	0.25
p.S401L	TCGA-EE-A3J5	SKCM	TCGA	PEPTPPTT	DEG_SCF_FBW7_1	0.1944
p.A420V	TCGA-IB-7651	PAAD	TCGA	PEPTPPTT	DEG_SCF_FBW7_1	0.1389
p.P409L	DO229177	LMS	ICGC	PEPTPPTT	DEG_SCF_FBW7_1	0.7582
p.P401A	DO45517	LUSC	ICGC	PEPTPPTT	DEG_SCF_FBW7_1	0.1944
p.A418V	DO46657	PAAD	ICGC	PEPTPPTT	DEG_SCF_FBW7_1	0.1944
p.A418V	ACH-001991	Primary	CCLE	PEPTPPTT	DEG_SCF_FBW7_1	0.1944
p.S423F	DO37432	SKCM	ICGC	PEPTPPTT	DEG_SCF_FBW7_1	0.0556
p.S399L	DO47331	SKCM	ICGC	PEPTPPTT	DEG_SCF_FBW7_1	0.1389
p.S396F	SIDM00333	Endometrial Carcinoma	GDSC	PEPTPPTT	DEG_SCF_FBW7_1	0.0556
p.S396F	ACH-000988	Endometrial/Uterine Cancer	CCLE	PEPTPPTT	DEG_SCF_FBW7_1	0.0556
p.S396F	MFE-319	endometrium	COSMIC	PEPTPPTT	DEG_SCF_FBW7_1	0.0556
p.A415S	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	PEPTPPTT	DEG_SCF_FBW7_1	0.2778
p.A415S	ACH-000888	Lung Cancer	CCLE	PEPTPPTT	DEG_SCF_FBW7_1	0.2778
p.A415S	NCI-H1793	lung	COSMIC	PEPTPPTT	DEG_SCF_FBW7_1	0.2778
p.S421P	SIDM01608	Endometrial Carcinoma	GDSC	PEPTPPTT	DEG_SCF_FBW7_1	0.1111
p.S421P	ACH-000990	Endometrial/Uterine Cancer	CCLE	PEPTPPTT	DEG_SCF_FBW7_1	0.1111
p.T412A	ACH-001699	Head and Neck Cancer	CCLE	PEPTPPTT	DEG_SCF_FBW7_1	0.6028
p.A413S	NCI-H1793	lung	COSMIC	PEPTPPTT	DEG_SCF_FBW7_1	0.7588
p.D416E	ECC10	stomach	COSMIC	PEPTPPTT	DEG_SCF_FBW7_1	0.25
p.G415R	NCI-H446	lung	COSMIC	PEPTPPTT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60641	Clathrin coat assembly protein AP180	DEG_SCF_FBW7_1	406:413	PEPTPPTT	FBXW7	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons