DegronMD

Uniprot ID: A8K4G0

Source protein: CMRF35-like molecule 7

Source gene: CD300LB

Class: DEG_SPOP_SBC_1

Location: 126:130

E3 ligase: SPOP

DEGRON score: 0.5335

ASA_SCORE: 77.08

COIL: 0.759

CONS_SCORE: 0.1028

DSS_SCORE: 0.5009

HELIX: 0.0298

FCONS_SCORE: 0.4392

RIG_SCORE: 0.6772

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R132G	TCGA-55-7907	LUAD	TCGA	AASTT	DEG_SPOP_SBC_1	0.2778
p.R132G	DO25396	LUAD	ICGC	AASTT	DEG_SPOP_SBC_1	0.2778
p.R122H	TCGA-AF-A56N	READ	TCGA	AASTT	DEG_SPOP_SBC_1	0.2222
p.R122H	DO50277	READ	ICGC	AASTT	DEG_SPOP_SBC_1	0.2222
p.A136T	TCGA-AX-A1CE	UCEC	TCGA	AASTT	DEG_SPOP_SBC_1	0.1667
p.A136T	DO42280	UCEC	ICGC	AASTT	DEG_SPOP_SBC_1	0.1667
p.V138A	TCGA-BR-8680	STAD	TCGA	AASTT	DEG_SPOP_SBC_1	0.1111
p.V138A	DO47769	STAD	ICGC	AASTT	DEG_SPOP_SBC_1	0.1111
p.T123M	TCGA-DB-A64S	LGG	TCGA	AASTT	DEG_SPOP_SBC_1	0.25
p.T123M	TCGA-FI-A2D0	UCEC	TCGA	AASTT	DEG_SPOP_SBC_1	0.25
p.T123M	TCGA-FW-A3R5	SKCM	TCGA	AASTT	DEG_SPOP_SBC_1	0.25
p.T123M	TCGA-HC-8213	PRAD	TCGA	AASTT	DEG_SPOP_SBC_1	0.25
p.T123M	DO233210	GACA	ICGC	AASTT	DEG_SPOP_SBC_1	0.25
p.T123M	DO44619	LGG	ICGC	AASTT	DEG_SPOP_SBC_1	0.25
p.T123M	DO49812	PRAD	ICGC	AASTT	DEG_SPOP_SBC_1	0.25
p.T123M	DO37406	SKCM	ICGC	AASTT	DEG_SPOP_SBC_1	0.25
p.T123M	DO43891	UCEC	ICGC	AASTT	DEG_SPOP_SBC_1	0.25
p.D134Y	TCGA-DX-A7EU	SARC	TCGA	AASTT	DEG_SPOP_SBC_1	0.2222
p.D134Y	DO220040	SARC	ICGC	AASTT	DEG_SPOP_SBC_1	0.2222
p.R122C	TCGA-FA-8693	DLBC	TCGA	AASTT	DEG_SPOP_SBC_1	0.2222
p.R122C	DO219884	DLBC	ICGC	AASTT	DEG_SPOP_SBC_1	0.2222
p.T123S	TCGA-FW-A3R5	SKCM	TCGA	AASTT	DEG_SPOP_SBC_1	0.25
p.T123S	DO37406	SKCM	ICGC	AASTT	DEG_SPOP_SBC_1	0.25
p.E129D	TCGA-HU-A4GU	STAD	TCGA	AASTT	DEG_SPOP_SBC_1	0.6758
p.E129D	DO47849	STAD	ICGC	AASTT	DEG_SPOP_SBC_1	0.6758
p.R122S	DO229035	LICA	ICGC	AASTT	DEG_SPOP_SBC_1	0.2222
p.T123K	DO229035	LICA	ICGC	AASTT	DEG_SPOP_SBC_1	0.25
p.N136D	SIDM01083	Oral Cavity Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	0.1667
p.N136D	SCC-15	upper_aerodigestive_tract	COSMIC	AASTT	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8K4G0	CMRF35-like molecule 7	DEG_SPOP_SBC_1	126:130	AASTT	SPOP	0.5335	More...
O00592	Podocalyxin	DEG_SPOP_SBC_1	320:324	AASTT	SPOP	0.9973	More...
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	642:646	AASTT	SPOP	0.9917	More...
P28356	Homeobox protein Hox-D9	DEG_SPOP_SBC_1	173:177	AASTT	SPOP	0.9609	More...
P55318	Hepatocyte nuclear factor 3-gamma	DEG_SPOP_SBC_1	237:241	AASTT	SPOP	0.7405	More...
Q02086	Transcription factor Sp2	DEG_SPOP_SBC_1	23:27	AASTT	SPOP	0.9884	More...
Q5JR59	Microtubule-associated tumor suppressor candidate 2	DEG_SPOP_SBC_1	959:963	AASTT	SPOP	0.869	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	2203:2207	AASTT	SPOP	0.7885	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	1974:1978	AASTT	SPOP	0.5287	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	1087:1091	AASTT	SPOP	0.5559	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	3497:3501	AASTT	SPOP	0.9452	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	3529:3533	AASTT	SPOP	0.6297	More...
Q96DR8	Mucin-like protein 1	DEG_SPOP_SBC_1	64:68	AASTT	SPOP	0.9933	More...
Q9Y4G6	Talin-2	DEG_SPOP_SBC_1	1141:1145	AASTT	SPOP	0.6347	More...
Q504T8	Midnolin	DEG_SPOP_SBC_1	225:229	AASTT	SPOP	0.9923	More...
Q53QW1	Testis-expressed protein 44	DEG_SPOP_SBC_1	186:190	AASTT	SPOP	0.8941	More...
Q6UXI7	Vitrin	DEG_SPOP_SBC_1	207:211	AASTT	SPOP	0.5243	More...
Q8WUT4	Leucine-rich repeat neuronal protein 4	DEG_SPOP_SBC_1	449:453	AASTT	SPOP	0.9591	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	418:422	AASTT	SPOP	0.9307	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	537:541	AASTT	SPOP	0.7877	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1527:1531	AASTT	SPOP	0.6149	More...
Q9NRJ2	Putative uncharacterized protein GSN-AS1	DEG_SPOP_SBC_1	133:137	AASTT	SPOP	0.9628	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AASTT

Degron related mutations and impact score

Drug responses associated with CD300LB mutations

All proteins holding degron of AASTT