DegronMD - Q8WUT4(LRRN4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E94K	TCGA-50-5072	LUAD	TCGA	ALSTS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.3056
p.E94K	TCGA-DU-5871	LGG	TCGA	ALSTS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.3056
p.E94K	DO22318	LGG	ICGC	ALSTS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.3056
p.E94K	DO25967	LUAD	ICGC	ALSTS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.3056
p.R2Q	TCGA-AJ-A3EK	UCEC	TCGA	MRQTLPLLL	DEG_APCC_DBOX_1	1:9	Mutation altering degron motif	0.7329
p.R2Q	DO41584	UCEC	ICGC	MRQTLPLLL	DEG_APCC_DBOX_1	1:9	Mutation altering degron motif	0.7329
p.V445I	TCGA-BR-8372	STAD	TCGA	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.2222
p.V445I	DO233854	GACA	ICGC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.2222
p.V445I	DO47873	STAD	ICGC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.2222
p.R14C	TCGA-CD-8527	STAD	TCGA	MRQTLPLLL	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.1944
p.R14C	DO227996	COCA	ICGC	MRQTLPLLL	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.1944
p.R14C	DO47739	STAD	ICGC	MRQTLPLLL	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.1944
p.P447H	TCGA-D3-A2J6	SKCM	TCGA	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.2778
p.P447H	DO37901	SKCM	ICGC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.2778
p.S436C	TCGA-D3-A3BZ	SKCM	TCGA	APSTT	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.2778
p.S436C	DO47513	SKCM	ICGC	APSTT	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.2778
p.G459V	TCGA-DD-AACX	LIHC	TCGA	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.1667
p.G459V	DO52215	LIHC	ICGC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.1667
p.R426L	TCGA-DJ-A2QB	THCA	TCGA	APSTT	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.2222
p.R426L	DO39421	THCA	ICGC	APSTT	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.2222
p.S436Y	TCGA-DX-A6YV	SARC	TCGA	APSTT	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.2778
p.S436Y	DO220011	SARC	ICGC	APSTT	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.2778
p.R88P	TCGA-MQ-A4LP	MESO	TCGA	ALSTS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.3056
p.T433M	DO222817	BTCA	ICGC	APSTT	DEG_SPOP_SBC_1	430:434	Mutation altering degron motif	0.7423
p.R426W	DO230312	COCA	ICGC	APSTT	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.2222
p.R454S	DO229016	COCA	ICGC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	DO231026	LUSC	ICGC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM01020	Plasma Cell Myeloma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00338	Acute Myeloid Leukemia	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00353	Other Sarcomas	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00582	Pancreatic Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00586	Hepatocellular Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00234	Other Solid Cancers	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00617	Hepatocellular Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM01040	Ovarian Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00064	Hepatocellular Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00535	Chondrosarcoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00602	Gastric Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00157	Neuroblastoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00607	Glioblastoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00315	Glioblastoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00362	Burkitt's Lymphoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00533	Pancreatic Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00466	Ovarian Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM01093	Cervical Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM01097	Other Solid Cancers	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM01045	Endometrial Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00585	Hepatocellular Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00252	Biliary Tract Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00276	Biliary Tract Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00214	Colorectal Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00240	Cervical Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00397	Acute Myeloid Leukemia	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00655	Other Solid Cancers	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00271	Gastric Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00324	Neuroblastoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00241	Breast Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00316	Glioblastoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00274	Gastric Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00273	Glioblastoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM01728	Endometrial Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM01617	Endometrial Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM01412	Oral Cavity Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM01336	Glioblastoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM01598	Non-Small Cell Lung Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM01472	Hepatocellular Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM01435	Hepatocellular Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM01691	Chronic Myelogenous Leukemia	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM01450	Gastric Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM01378	Ovarian Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM01782	Oral Cavity Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00959	Acute Myeloid Leukemia	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM00164	Biliary Tract Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM01774	Pancreatic Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM01753	Gastric Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R454S	SIDM01618	B-Lymphoblastic Leukemia	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.A18S	DO233619	GACA	ICGC	MRQTLPLLL	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.0833
p.A18V	DO233619	GACA	ICGC	MRQTLPLLL	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.0833
p.H84N	DO228985	LICA	ICGC	ALSTS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1944
p.R14S	DO229028	LICA	ICGC	MRQTLPLLL	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.1944
p.A18E	DO229032	LICA	ICGC	MRQTLPLLL	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.0833
p.A425T	DO35394	PACA	ICGC	APSTT	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.1944
p.P15S	DO37827	SKCM	ICGC	MRQTLPLLL	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.1667
p.D81G	DO229181	THCA	ICGC	ALSTS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1111
p.S16N	SIDM02059	Colorectal Carcinoma	GDSC	MRQTLPLLL	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.1389
p.S441N	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	APSTT	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.1389
p.S441N	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.1111
p.S441N	ACH-000914	Lymphoma	CCLE	APSTT	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.1389
p.S441N	ACH-000914	Lymphoma	CCLE	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.1111
p.S441N	HT	haematopoietic and lymphoid tissue	COSMIC	APSTT	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.1389
p.S441N	HT	haematopoietic and lymphoid tissue	COSMIC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.1111
p.N85I	SIDM00454	Rhabdomyosarcoma	GDSC	ALSTS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.2222
p.N85I	SIDM01525	Acute Myeloid Leukemia	GDSC	ALSTS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.2222
p.S451G	SIDM00210	Ovarian Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation altering degron motif	0.6993
p.S451G	SIDM01099	Neuroblastoma	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation altering degron motif	0.6993
p.S451G	SIDM00694	Other Solid Cancers	GDSC	AASTT	DEG_SPOP_SBC_1	449:453	Mutation altering degron motif	0.6993
p.P421L	SIDM00783	Colorectal Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.0833
p.P421L	ACH-000971	Colon/Colorectal Cancer	CCLE	APSTT	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.0833
p.P421L	HCT-116	large intestine	COSMIC	APSTT	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.0833
p.A89T	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	ALSTS	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.7139
p.A89T	ACH-000925	Lung Cancer	CCLE	ALSTS	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.7139
p.R14H	ACH-000930	Breast Cancer	CCLE	MRQTLPLLL	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.1944
p.P15H	ACH-001036	Leukemia	CCLE	MRQTLPLLL	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRRN4

UniProt ID: Q8WUT4

Entrez ID: 164312

Protein name: Leucine-rich repeat neuronal protein 4 (Neuronal leucine-rich repeat protein 4) (NLRR-4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRRN4 in