DegronMD

Uniprot ID: Q8WUT4

Source protein: Leucine-rich repeat neuronal protein 4

Source gene: LRRN4

Class: DEG_APCC_DBOX_1

Location: 1:9

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9164

ASA_SCORE: 103.2444

COIL: 0.6228

CONS_SCORE: 0.5951

DSS_SCORE: 0.4559

HELIX: 0.2888

FCONS_SCORE: 1.8601

RIG_SCORE: 0.8473

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2Q	TCGA-AJ-A3EK	UCEC	TCGA	MRQTLPLLL	DEG_APCC_DBOX_1	0.7329
p.R2Q	DO41584	UCEC	ICGC	MRQTLPLLL	DEG_APCC_DBOX_1	0.7329
p.R14C	TCGA-CD-8527	STAD	TCGA	MRQTLPLLL	DEG_APCC_DBOX_1	0.1944
p.R14C	DO227996	COCA	ICGC	MRQTLPLLL	DEG_APCC_DBOX_1	0.1944
p.R14C	DO47739	STAD	ICGC	MRQTLPLLL	DEG_APCC_DBOX_1	0.1944
p.A18S	DO233619	GACA	ICGC	MRQTLPLLL	DEG_APCC_DBOX_1	0.0833
p.A18V	DO233619	GACA	ICGC	MRQTLPLLL	DEG_APCC_DBOX_1	0.0833
p.R14S	DO229028	LICA	ICGC	MRQTLPLLL	DEG_APCC_DBOX_1	0.1944
p.A18E	DO229032	LICA	ICGC	MRQTLPLLL	DEG_APCC_DBOX_1	0.0833
p.P15S	DO37827	SKCM	ICGC	MRQTLPLLL	DEG_APCC_DBOX_1	0.1667
p.S16N	SIDM02059	Colorectal Carcinoma	GDSC	MRQTLPLLL	DEG_APCC_DBOX_1	0.1389
p.R14H	ACH-000930	Breast Cancer	CCLE	MRQTLPLLL	DEG_APCC_DBOX_1	0.1944
p.P15H	ACH-001036	Leukemia	CCLE	MRQTLPLLL	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WUT4	Leucine-rich repeat neuronal protein 4	DEG_APCC_DBOX_1	1:9	MRQTLPLLL	APC,CDC20,FZR1	0.9164	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons