DegronMD

Uniprot ID: Q8WUT4

Source protein: Leucine-rich repeat neuronal protein 4

Source gene: LRRN4

Class: DEG_SPOP_SBC_1

Location: 89:93

E3 ligase: SPOP

DEGRON score: 0.8851

ASA_SCORE: 52.9

COIL: 0.7614

CONS_SCORE: 0.5317

DSS_SCORE: 0.2034

HELIX: 0.0794

FCONS_SCORE: 0.7945

RIG_SCORE: 0.7493

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E94K	TCGA-50-5072	LUAD	TCGA	ALSTS	DEG_SPOP_SBC_1	0.3056
p.E94K	TCGA-DU-5871	LGG	TCGA	ALSTS	DEG_SPOP_SBC_1	0.3056
p.E94K	DO22318	LGG	ICGC	ALSTS	DEG_SPOP_SBC_1	0.3056
p.E94K	DO25967	LUAD	ICGC	ALSTS	DEG_SPOP_SBC_1	0.3056
p.R88P	TCGA-MQ-A4LP	MESO	TCGA	ALSTS	DEG_SPOP_SBC_1	0.3056
p.H84N	DO228985	LICA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.1944
p.D81G	DO229181	THCA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.1111
p.N85I	SIDM00454	Rhabdomyosarcoma	GDSC	ALSTS	DEG_SPOP_SBC_1	0.2222
p.N85I	SIDM01525	Acute Myeloid Leukemia	GDSC	ALSTS	DEG_SPOP_SBC_1	0.2222
p.A89T	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	ALSTS	DEG_SPOP_SBC_1	0.7139
p.A89T	ACH-000925	Lung Cancer	CCLE	ALSTS	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15055	Period circadian protein homolog 2	DEG_SPOP_SBC_1	1049:1053	ALSTS	SPOP	0.9657	More...
P04198	N-myc proto-oncogene protein	DEG_SPOP_SBC_1	251:255	ALSTS	SPOP	0.9983	More...
P85298	Rho GTPase-activating protein 8	DEG_SPOP_SBC_1	7:11	ALSTS	SPOP	0.6295	More...
Q14190	Single-minded homolog 2	DEG_SPOP_SBC_1	359:363	ALSTS	SPOP	0.9978	More...
Q8IZL2	Mastermind-like protein 2	DEG_SPOP_SBC_1	397:401	ALSTS	SPOP	0.9214	More...
Q92558	Wiskott-Aldrich syndrome protein family member 1	DEG_SPOP_SBC_1	334:338	ALSTS	SPOP	0.8439	More...
Q96F81	Protein dispatched homolog 1	DEG_SPOP_SBC_1	1157:1161	ALSTS	SPOP	0.6075	More...
Q96QB1	Rho GTPase-activating protein 7	DEG_SPOP_SBC_1	372:376	ALSTS	SPOP	0.9989	More...
Q99593	T-box transcription factor TBX5	DEG_SPOP_SBC_1	280:284	ALSTS	SPOP	0.7853	More...
Q9H0U6	39S ribosomal protein L18, mitochondrial	DEG_SPOP_SBC_1	23:27	ALSTS	SPOP	0.8755	More...
Q8WUT4	Leucine-rich repeat neuronal protein 4	DEG_SPOP_SBC_1	89:93	ALSTS	SPOP	0.8851	More...
Q8IZM8	Zinc finger protein 654	DEG_SPOP_SBC_1	532:536	ALSTS	SPOP	0.8723	More...
Q8NDW4	Zinc finger protein 248	DEG_SPOP_SBC_1	575:579	ALSTS	SPOP	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons