DegronMD

Uniprot ID: O15055

Source protein: Period circadian protein homolog 2

Source gene: PER2

Class: DEG_SPOP_SBC_1

Location: 1049:1053

E3 ligase: SPOP

DEGRON score: 0.9657

ASA_SCORE: 73.62

COIL: 0.7146

CONS_SCORE: 0.4639

DSS_SCORE: 0.5105

HELIX: 0.2504

FCONS_SCORE: 1.2129

RIG_SCORE: 0.6938

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1042L	TCGA-MP-A4TK	LUAD	TCGA	ALSTS	DEG_SPOP_SBC_1	0.1389
p.S1042L	DO45384	LUAD	ICGC	ALSTS	DEG_SPOP_SBC_1	0.1389
p.S1047T	DO48398	BLCA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.2778
p.A1049T	DO233203	GACA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.7139
p.A1049T	DO233760	GACA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.7139
p.A1049T	SIDM00572	Gastric Carcinoma	GDSC	ALSTS	DEG_SPOP_SBC_1	0.7139
p.A1049T	ACH-000911	Gastric Cancer	CCLE	ALSTS	DEG_SPOP_SBC_1	0.7139
p.A1049T	NUGC-3	stomach	COSMIC	ALSTS	DEG_SPOP_SBC_1	0.7139
p.N1046K	DO229018	LICA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.25
p.E1063D	DO232761	PBCA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.0556
p.D1048N	SIDM00353	Other Sarcomas	GDSC	ALSTS	DEG_SPOP_SBC_1	0.3056
p.D1048N	SIDM01259	B-Lymphoblastic Leukemia	GDSC	ALSTS	DEG_SPOP_SBC_1	0.3056
p.D1048N	ACH-000505	Sarcoma	CCLE	ALSTS	DEG_SPOP_SBC_1	0.3056
p.D1048N	ACH-001669	Leukemia	CCLE	ALSTS	DEG_SPOP_SBC_1	0.3056
p.D1048N	ACH-002238	Leukemia	CCLE	ALSTS	DEG_SPOP_SBC_1	0.3056
p.D1048N	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	ALSTS	DEG_SPOP_SBC_1	0.3056
p.D1048N	RKN	ovary	COSMIC	ALSTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15055	Period circadian protein homolog 2	DEG_SPOP_SBC_1	1049:1053	ALSTS	SPOP	0.9657	More...
P04198	N-myc proto-oncogene protein	DEG_SPOP_SBC_1	251:255	ALSTS	SPOP	0.9983	More...
P85298	Rho GTPase-activating protein 8	DEG_SPOP_SBC_1	7:11	ALSTS	SPOP	0.6295	More...
Q14190	Single-minded homolog 2	DEG_SPOP_SBC_1	359:363	ALSTS	SPOP	0.9978	More...
Q8IZL2	Mastermind-like protein 2	DEG_SPOP_SBC_1	397:401	ALSTS	SPOP	0.9214	More...
Q92558	Wiskott-Aldrich syndrome protein family member 1	DEG_SPOP_SBC_1	334:338	ALSTS	SPOP	0.8439	More...
Q96F81	Protein dispatched homolog 1	DEG_SPOP_SBC_1	1157:1161	ALSTS	SPOP	0.6075	More...
Q96QB1	Rho GTPase-activating protein 7	DEG_SPOP_SBC_1	372:376	ALSTS	SPOP	0.9989	More...
Q99593	T-box transcription factor TBX5	DEG_SPOP_SBC_1	280:284	ALSTS	SPOP	0.7853	More...
Q9H0U6	39S ribosomal protein L18, mitochondrial	DEG_SPOP_SBC_1	23:27	ALSTS	SPOP	0.8755	More...
Q8WUT4	Leucine-rich repeat neuronal protein 4	DEG_SPOP_SBC_1	89:93	ALSTS	SPOP	0.8851	More...
Q8IZM8	Zinc finger protein 654	DEG_SPOP_SBC_1	532:536	ALSTS	SPOP	0.8723	More...
Q8NDW4	Zinc finger protein 248	DEG_SPOP_SBC_1	575:579	ALSTS	SPOP	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons