DegronMD

Uniprot ID: Q9H0U6

Source protein: 39S ribosomal protein L18, mitochondrial

Source gene: MRPL18

Class: DEG_SPOP_SBC_1

Location: 23:27

E3 ligase: SPOP

DEGRON score: 0.8755

ASA_SCORE: 60.74

COIL: 0.6328

CONS_SCORE: 0.3323

DSS_SCORE: 0.3528

HELIX: 0.062

FCONS_SCORE: 1.1851

RIG_SCORE: 0.7092

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S27R	DO232224	PBCA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.7427
p.S27N	DO52661	MALY	ICGC	ALSTS	DEG_SPOP_SBC_1	0.7069
p.F21L	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	ALSTS	DEG_SPOP_SBC_1	0.2778
p.F21L	ACH-000914	Lymphoma	CCLE	ALSTS	DEG_SPOP_SBC_1	0.2778
p.F21L	HT	haematopoietic_and_lymphoid_tissue	COSMIC	ALSTS	DEG_SPOP_SBC_1	0.2778
p.A32V	TCGA-A6-5661	COAD	TCGA	ALSTS	DEG_SPOP_SBC_1	0.1944
p.A32V	DO8634	COAD	ICGC	ALSTS	DEG_SPOP_SBC_1	0.1944
p.A32V	DO229018	LICA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.1944
p.D37G	TCGA-FI-A2D5	UCEC	TCGA	ALSTS	DEG_SPOP_SBC_1	0.0556
p.D37G	DO41331	UCEC	ICGC	ALSTS	DEG_SPOP_SBC_1	0.0556
p.D37H	SIDM01186	Breast Carcinoma	GDSC	ALSTS	DEG_SPOP_SBC_1	0.0556
p.D37H	ACH-000554	Breast Cancer	CCLE	ALSTS	DEG_SPOP_SBC_1	0.0556
p.D37H	UACC-893	breast	COSMIC	ALSTS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 13 of 13 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H0U6	39S ribosomal protein L18, mitochondrial	DEG_SPOP_SBC_1	23:27	ALSTS	SPOP	0.8755	More...
Q8WUT4	Leucine-rich repeat neuronal protein 4	DEG_SPOP_SBC_1	89:93	ALSTS	SPOP	0.8851	More...
Q8IZL2	Mastermind-like protein 2	DEG_SPOP_SBC_1	397:401	ALSTS	SPOP	0.9214	More...
P04198	N-myc proto-oncogene protein	DEG_SPOP_SBC_1	251:255	ALSTS	SPOP	0.9983	More...
O15055	Period circadian protein homolog 2	DEG_SPOP_SBC_1	1049:1053	ALSTS	SPOP	0.9657	More...
Q96F81	Protein dispatched homolog 1	DEG_SPOP_SBC_1	1157:1161	ALSTS	SPOP	0.6075	More...
Q96QB1	Rho GTPase-activating protein 7	DEG_SPOP_SBC_1	372:376	ALSTS	SPOP	0.9989	More...
P85298	Rho GTPase-activating protein 8	DEG_SPOP_SBC_1	7:11	ALSTS	SPOP	0.6295	More...
Q14190	Single-minded homolog 2	DEG_SPOP_SBC_1	359:363	ALSTS	SPOP	0.9978	More...
Q99593	T-box transcription factor TBX5	DEG_SPOP_SBC_1	280:284	ALSTS	SPOP	0.7853	More...
Q92558	Wiskott-Aldrich syndrome protein family member 1	DEG_SPOP_SBC_1	334:338	ALSTS	SPOP	0.8439	More...
Q8NDW4	Zinc finger protein 248	DEG_SPOP_SBC_1	575:579	ALSTS	SPOP	0.9962	More...
Q8IZM8	Zinc finger protein 654	DEG_SPOP_SBC_1	532:536	ALSTS	SPOP	0.8723	More...

Showing 1 to 13 of 13 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons