DegronMD - Q96QB1(DLC1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R771W	TCGA-06-5416	GBM	TCGA	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation altering degron motif	0.8634
p.R771W	SIDM01007	T-Lymphoblastic Leukemia	GDSC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation altering degron motif	0.8634
p.R771W	ACH-002256	Leukemia	CCLE	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation altering degron motif	0.8634
p.R771W	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation altering degron motif	0.8634
p.Q784E	TCGA-13-0921	OV	TCGA	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.1389
p.Q784E	TCGA-13-0921	OV	TCGA	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.1389
p.Q784E	DO30230	OV	ICGC	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.1389
p.Q784E	DO30230	OV	ICGC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.1389
p.R994M	TCGA-44-7670	LUAD	TCGA	DSGVGAS	DEG_SCF_TRCP1_1	985:991	Mutation rewiring degron network	0.25
p.R994M	DO23555	LUAD	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	985:991	Mutation rewiring degron network	0.25
p.M774K	TCGA-46-3768	LUSC	TCGA	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation altering degron motif	0.8062
p.M774K	TCGA-46-3768	LUSC	TCGA	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation altering degron motif	0.8062
p.P616H	TCGA-56-8083	LUSC	TCGA	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation rewiring degron network	0.1111
p.P616H	DO223723	LUSC	ICGC	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation rewiring degron network	0.1111
p.T382R	TCGA-56-8308	LUSC	TCGA	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1667
p.T382R	DO219140	LUSC	ICGC	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1667
p.K677N	TCGA-58-A46M	LUSC	TCGA	TRSLLKRME	DEG_APCC_DBOX_1	664:672	Mutation substituting flanking lysine	0.3056
p.D366H	TCGA-60-2695	LUSC	TCGA	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1667
p.D366H	DO26665	LUSC	ICGC	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1667
p.H680N	TCGA-63-A5MI	LUSC	TCGA	TRSLLKRME	DEG_APCC_DBOX_1	664:672	Mutation rewiring degron network	0.1111
p.Q367K	TCGA-70-6722	LUSC	TCGA	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1944
p.Q367K	TCGA-E7-A7DV	BLCA	TCGA	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1944
p.Q367K	DO48583	BLCA	ICGC	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1944
p.Q367K	DO27755	LUSC	ICGC	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1944
p.G987V	TCGA-86-8358	LUAD	TCGA	DSGVGAS	DEG_SCF_TRCP1_1	985:991	Mutation altering degron motif	0.7532
p.G987V	DO25471	LUAD	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	985:991	Mutation altering degron motif	0.7532
p.G987A	TCGA-A2-A0D0	BRCA	TCGA	DSGVGAS	DEG_SCF_TRCP1_1	985:991	Mutation altering degron motif	0.754
p.S766N	TCGA-AA-3715	COAD	TCGA	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation blocking phosphorylation signal	0.6111
p.S766N	TCGA-AA-3715	COAD	TCGA	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation blocking phosphorylation signal	0.6389
p.S766N	DO8018	COAD	ICGC	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation blocking phosphorylation signal	0.6111
p.S766N	DO8018	COAD	ICGC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation blocking phosphorylation signal	0.6389
p.R665C	TCGA-AA-3949	COAD	TCGA	TRSLLKRME	DEG_APCC_DBOX_1	664:672	Mutation altering degron motif	0.8301
p.G638V	TCGA-AA-3986	COAD	TCGA	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation rewiring degron network	0.0556
p.T664M	TCGA-AX-A06F	UCEC	TCGA	TRSLLKRME	DEG_APCC_DBOX_1	664:672	Mutation altering degron motif	0.6312
p.R665H	TCGA-AX-A2HD	UCEC	TCGA	TRSLLKRME	DEG_APCC_DBOX_1	664:672	Mutation altering degron motif	0.8244
p.L373I	TCGA-AX-A2HD	UCEC	TCGA	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation altering degron motif	0.6063
p.L373I	DO42608	UCEC	ICGC	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation altering degron motif	0.6063
p.H998R	TCGA-B5-A11E	UCEC	TCGA	DSGVGAS	DEG_SCF_TRCP1_1	985:991	Mutation rewiring degron network	0.1389
p.H998R	DO41644	UCEC	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	985:991	Mutation rewiring degron network	0.1389
p.S682N	TCGA-B5-A11J	UCEC	TCGA	TRSLLKRME	DEG_APCC_DBOX_1	664:672	Mutation rewiring degron network	0.0556
p.R617Q	TCGA-BG-A0VW	UCEC	TCGA	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation rewiring degron network	0.1389
p.R617Q	SIDM01664	Prostate Carcinoma	GDSC	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation rewiring degron network	0.1389
p.G638D	TCGA-BR-4357	STAD	TCGA	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation rewiring degron network	0.0556
p.G638D	DO38241	STAD	ICGC	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation rewiring degron network	0.0556
p.G655C	TCGA-BR-8591	STAD	TCGA	TRSLLKRME	DEG_APCC_DBOX_1	664:672	Mutation rewiring degron network	0.0833
p.G655C	DO47973	STAD	ICGC	TRSLLKRME	DEG_APCC_DBOX_1	664:672	Mutation rewiring degron network	0.0833
p.E657K	TCGA-CI-6620	READ	TCGA	TRSLLKRME	DEG_APCC_DBOX_1	664:672	Mutation rewiring degron network	0.1389
p.E657K	DO36825	READ	ICGC	TRSLLKRME	DEG_APCC_DBOX_1	664:672	Mutation rewiring degron network	0.1389
p.R984S	TCGA-CN-A63U	HNSC	TCGA	DSGVGAS	DEG_SCF_TRCP1_1	985:991	Mutation rewiring degron network	0.3056
p.R984S	DO44454	HNSC	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	985:991	Mutation rewiring degron network	0.3056
p.A990S	TCGA-D1-A163	UCEC	TCGA	DSGVGAS	DEG_SCF_TRCP1_1	985:991	Mutation altering degron motif	0.6477
p.S620F	TCGA-D3-A3MV	SKCM	TCGA	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation rewiring degron network	0.2222
p.S620F	TCGA-D3-A5GO	SKCM	TCGA	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation rewiring degron network	0.2222
p.S620F	SIDM00974	Melanoma	GDSC	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation rewiring degron network	0.2222
p.S620F	ACH-002207	Skin Cancer	CCLE	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation rewiring degron network	0.2222
p.S620F	WM35	skin	COSMIC	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation rewiring degron network	0.2222
p.S679C	TCGA-D6-8568	HNSC	TCGA	TRSLLKRME	DEG_APCC_DBOX_1	664:672	Mutation rewiring degron network	0.1389
p.G989V	TCGA-EE-A3AA	SKCM	TCGA	DSGVGAS	DEG_SCF_TRCP1_1	985:991	Mutation altering degron motif	0.6421
p.A372T	TCGA-EO-A3AV	UCEC	TCGA	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation altering degron motif	0.7139
p.A372T	DO52412	UCEC	ICGC	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation altering degron motif	0.7139
p.S764R	TCGA-F1-6874	STAD	TCGA	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation blocking phosphorylation signal	0.5556
p.S764R	TCGA-F1-6874	STAD	TCGA	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation blocking phosphorylation signal	0.5833
p.A767V	TCGA-F4-6703	COAD	TCGA	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.1944
p.A767V	TCGA-F4-6703	COAD	TCGA	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.2222
p.A614T	TCGA-GU-AATO	BLCA	TCGA	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation rewiring degron network	0.0556
p.R670P	TCGA-HT-8011	LGG	TCGA	TRSLLKRME	DEG_APCC_DBOX_1	664:672	Mutation altering degron motif	0.6401
p.R670P	DO22197	LGG	ICGC	TRSLLKRME	DEG_APCC_DBOX_1	664:672	Mutation altering degron motif	0.6401
p.K675R	TCGA-IB-7651	PAAD	TCGA	TRSLLKRME	DEG_APCC_DBOX_1	664:672	Mutation substituting flanking lysine	0.3611
p.V624I	TCGA-MT-A51X	HNSC	TCGA	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation altering degron motif	0.7076
p.V624I	DO44441	HNSC	ICGC	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation altering degron motif	0.7076
p.D780Y	TCGA-O2-A5IB	LUSC	TCGA	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.25
p.D780Y	TCGA-O2-A5IB	LUSC	TCGA	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.25
p.D780Y	SIDM00660	Colorectal Carcinoma	GDSC	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.25
p.D780Y	SIDM00660	Colorectal Carcinoma	GDSC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.25
p.D780Y	ACH-000985	Colon/Colorectal Cancer	CCLE	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.25
p.D780Y	ACH-000985	Colon/Colorectal Cancer	CCLE	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.25
p.D780Y	LS-411N	large intestine	COSMIC	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.25
p.D780Y	LS-411N	large intestine	COSMIC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.25
p.H985Y	DO51920	BLCA	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	985:991	Mutation altering degron motif	0.7229
p.D368N	DO228246	BRCA	ICGC	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.2222
p.E362K	DO1073	BRCA	ICGC	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.0556
p.R783H	DO1162	BRCA	ICGC	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.1667
p.R783H	DO1162	BRCA	ICGC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.1667
p.R783H	DO43755	UCEC	ICGC	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.1667
p.R783H	DO43755	UCEC	ICGC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.1667
p.T368M	DO8447	COAD	ICGC	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.2222
p.D671E	DO8264	COAD	ICGC	TRSLLKRME	DEG_APCC_DBOX_1	664:672	Mutation altering degron motif	0.6758
p.S678N	DO230342	COCA	ICGC	TRSLLKRME	DEG_APCC_DBOX_1	664:672	Mutation rewiring degron network	0.1667
p.D368E	DO222588	COCA	ICGC	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.2222
p.R783C	DO222762	COCA	ICGC	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.1667
p.R783C	DO222762	COCA	ICGC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.1667
p.R783C	DO47769	STAD	ICGC	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.1667
p.R783C	DO47769	STAD	ICGC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.1667
p.S374R	DO218243	GACA	ICGC	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation altering degron motif	0.8538
p.R666Q	DO233154	GACA	ICGC	TRSLLKRME	DEG_APCC_DBOX_1	664:672	Mutation altering degron motif	0.7329
p.Y364S	DO233760	GACA	ICGC	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1111
p.Q765H	DO17492	KIRC	ICGC	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.1389
p.Q765H	DO17492	KIRC	ICGC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.1667
p.P383Q	DO228952	LICA	ICGC	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1389
p.N781K	DO228976	LICA	ICGC	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.2222
p.N781K	DO228976	LICA	ICGC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.2222
p.F782L	DO229038	LICA	ICGC	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.1944
p.F782L	DO229038	LICA	ICGC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.1944
p.E777K	DO26506	LUSC	ICGC	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation altering degron motif	0.7022
p.E777K	DO26506	LUSC	ICGC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation altering degron motif	0.7022
p.R994I	DO222562	MELA	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	985:991	Mutation rewiring degron network	0.25
p.S679L	DO232761	PBCA	ICGC	TRSLLKRME	DEG_APCC_DBOX_1	664:672	Mutation rewiring degron network	0.1389
p.S679L	DO36556	READ	ICGC	TRSLLKRME	DEG_APCC_DBOX_1	664:672	Mutation rewiring degron network	0.1389
p.G620C	DO47299	SKCM	ICGC	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation rewiring degron network	0.2222
p.P785T	DO37431	SKCM	ICGC	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.1111
p.P785T	DO37431	SKCM	ICGC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.1111
p.Q782H	DO47578	SKCM	ICGC	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.1944
p.Q782H	DO47578	SKCM	ICGC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.1944
p.P378S	DO51761	STAD	ICGC	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.2778
p.L767M	DO39552	THCA	ICGC	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.1944
p.L767M	DO39552	THCA	ICGC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.2222
p.P631S	DO42023	UCEC	ICGC	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation rewiring degron network	0.25
p.A994V	DO41752	UCEC	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	985:991	Mutation rewiring degron network	0.25
p.R663Q	DO42713	UCEC	ICGC	TRSLLKRME	DEG_APCC_DBOX_1	664:672	Mutation rewiring degron network	0.3056
p.V621I	SIDM00216	Colorectal Carcinoma	GDSC	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation rewiring degron network	0.25
p.V621I	ACH-000989	Colon/Colorectal Cancer	CCLE	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation rewiring degron network	0.25
p.V621I	SNU-175	large intestine	COSMIC	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation rewiring degron network	0.25
p.N783S	SIDM00086	Kidney Carcinoma	GDSC	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.1667
p.N783S	SIDM00086	Kidney Carcinoma	GDSC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.1667
p.N783S	SIDM00459	B-Cell Non-Hodgkin's Lymphoma	GDSC	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.1667
p.N783S	SIDM00459	B-Cell Non-Hodgkin's Lymphoma	GDSC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.1667
p.N783S	SIDM00209	Glioblastoma	GDSC	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.1667
p.N783S	SIDM00209	Glioblastoma	GDSC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.1667
p.N783S	D-423MG	central nervous system	COSMIC	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.1667
p.N783S	D-423MG	central nervous system	COSMIC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.1667
p.N783S	OCI-LY7	haematopoietic and lymphoid tissue	COSMIC	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.1667
p.N783S	OCI-LY7	haematopoietic and lymphoid tissue	COSMIC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.1667
p.N783K	SIDM00120	Prostate Carcinoma	GDSC	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.1667
p.N783K	SIDM00120	Prostate Carcinoma	GDSC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.1667
p.N783K	ACH-000979	Prostate Cancer	CCLE	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.1667
p.N783K	ACH-000979	Prostate Cancer	CCLE	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.1667
p.N783K	DU-145	prostate	COSMIC	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.1667
p.N783K	DU-145	prostate	COSMIC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.1667
p.P383S	SIDM01175	Other Sarcomas	GDSC	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1389
p.P383S	ACH-002309	Sarcoma	CCLE	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1389
p.P383S	SW684	soft tissue	COSMIC	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1389
p.I622V	SIDM00652	Small Cell Lung Carcinoma	GDSC	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation rewiring degron network	0.2778
p.I622V	ACH-000780	Lung Cancer	CCLE	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation rewiring degron network	0.2778
p.I622V	NCI-H1105	lung	COSMIC	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation rewiring degron network	0.2778
p.H998Q	SIDM00014	Colorectal Carcinoma	GDSC	DSGVGAS	DEG_SCF_TRCP1_1	985:991	Mutation rewiring degron network	0.1389
p.S626F	SIDM00638	Cervical Carcinoma	GDSC	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation altering degron motif	0.7982
p.S626F	ACH-001360	Cervical Cancer	CCLE	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation altering degron motif	0.7982
p.S626F	MS751	cervix	COSMIC	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation altering degron motif	0.7982
p.N380S	OCI-LY7	haematopoietic and lymphoid tissue	COSMIC	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.2222
p.N380S	D-423MG	central nervous system	COSMIC	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.2222
p.R1001Q	HT-115	large intestine	COSMIC	DSGVGAS	DEG_SCF_TRCP1_1	985:991	Mutation rewiring degron network	0.0556
p.K676T	HCT-15	large intestine	COSMIC	TRSLLKRME	DEG_APCC_DBOX_1	664:672	Mutation rewiring degron network	0.2222
p.V622A	HCT-116	large intestine	COSMIC	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation rewiring degron network	0.2778
p.P986L	SW684	soft tissue	COSMIC	DSGVGAS	DEG_SCF_TRCP1_1	985:991	Mutation altering degron motif	0.7582
p.V991A	SNU-1040	large intestine	COSMIC	DSGVGAS	DEG_SCF_TRCP1_1	985:991	Mutation altering degron motif	0.6936
p.R1001W	SNU-1040	large intestine	COSMIC	DSGVGAS	DEG_SCF_TRCP1_1	985:991	Mutation rewiring degron network	0.0556
p.A674V	KM12	large intestine	COSMIC	TRSLLKRME	DEG_APCC_DBOX_1	664:672	Mutation rewiring degron network	0.2778
p.D377Y	LS-411N	large intestine	COSMIC	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.3056
p.C669Y	CAL-12T	lung	COSMIC	TRSLLKRME	DEG_APCC_DBOX_1	664:672	Mutation altering degron motif	0.7087
p.A782V	KM12	large intestine	COSMIC	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.1944
p.A782V	KM12	large intestine	COSMIC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.1944
p.A620D	DG-75	haematopoietic and lymphoid tissue	COSMIC	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation rewiring degron network	0.2222
p.C769Y	DEL	haematopoietic and lymphoid tissue	COSMIC	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.25
p.C769Y	DEL	haematopoietic and lymphoid tissue	COSMIC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.2778
p.R368W	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.2222
p.A654D	DG-75	haematopoietic and lymphoid tissue	COSMIC	TRSLLKRME	DEG_APCC_DBOX_1	664:672	Mutation substituting flanking lysine	0.1667
p.A987S	NCI-H441	lung	COSMIC	DSGVGAS	DEG_SCF_TRCP1_1	985:991	Mutation altering degron motif	0.7588
p.P776S	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation altering degron motif	0.6752
p.P776S	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation altering degron motif	0.6752
p.N380K	DU-145	prostate	COSMIC	ALSTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.2222
p.E628G	CCK-81	large intestine	COSMIC	VCSSS	DEG_SPOP_SBC_1	624:628	Mutation altering degron motif	0.7199
p.K784T	HCT-15	large intestine	COSMIC	VGMYLE	LIG_APCC_ABBA_1	772:777	Mutation rewiring degron network	0.1389
p.K784T	HCT-15	large intestine	COSMIC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	771:777	Mutation rewiring degron network	0.1389
p.H668R	OVISE	ovary	COSMIC	TRSLLKRME	DEG_APCC_DBOX_1	664:672	Mutation altering degron motif	0.8244

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DLC1

UniProt ID: Q96QB1

Entrez ID: 10395

Protein name: Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DLC1 in