DegronMD

Uniprot ID: Q96QB1

Source protein: Rho GTPase-activating protein 7

Source gene: DLC1

Class: LIG_APCC_ABBAyCdc20_2

Location: 771:777

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8802

ASA_SCORE: 65.3714

COIL: 0.5714

CONS_SCORE: 0.3594

DSS_SCORE: 0.3141

HELIX: 0.1584

FCONS_SCORE: 1.0254

RIG_SCORE: 0.7976

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R771W	TCGA-06-5416	GBM	TCGA	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.8634
p.R771W	SIDM01007	T-Lymphoblastic Leukemia	GDSC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.8634
p.R771W	ACH-002256	Leukemia	CCLE	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.8634
p.R771W	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.8634
p.Q784E	TCGA-13-0921	OV	TCGA	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.Q784E	DO30230	OV	ICGC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.M774K	TCGA-46-3768	LUSC	TCGA	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.8062
p.S766N	TCGA-AA-3715	COAD	TCGA	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.6389
p.S766N	DO8018	COAD	ICGC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.6389
p.S764R	TCGA-F1-6874	STAD	TCGA	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.5833
p.A767V	TCGA-F4-6703	COAD	TCGA	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.2222
p.D780Y	TCGA-O2-A5IB	LUSC	TCGA	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.25
p.D780Y	SIDM00660	Colorectal Carcinoma	GDSC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.25
p.D780Y	ACH-000985	Colon/Colorectal Cancer	CCLE	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.25
p.D780Y	LS-411N	large_intestine	COSMIC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.25
p.R783H	DO1162	BRCA	ICGC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R783H	DO43755	UCEC	ICGC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R783C	DO222762	COCA	ICGC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R783C	DO47769	STAD	ICGC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.Q765H	DO17492	KIRC	ICGC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.N781K	DO228976	LICA	ICGC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.2222
p.F782L	DO229038	LICA	ICGC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.1944
p.E777K	DO26506	LUSC	ICGC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.7022
p.P785T	DO37431	SKCM	ICGC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.1111
p.Q782H	DO47578	SKCM	ICGC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.1944
p.L767M	DO39552	THCA	ICGC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.2222
p.N783S	SIDM00086	Kidney Carcinoma	GDSC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.N783S	SIDM00459	B-Cell Non-Hodgkin's Lymphoma	GDSC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.N783S	SIDM00209	Glioblastoma	GDSC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.N783S	D-423MG	central_nervous_system	COSMIC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.N783S	OCI-LY7	haematopoietic_and_lymphoid_tissue	COSMIC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.N783K	SIDM00120	Prostate Carcinoma	GDSC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.N783K	ACH-000979	Prostate Cancer	CCLE	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.N783K	DU-145	prostate	COSMIC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.A782V	KM12	large_intestine	COSMIC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.1944
p.C769Y	DEL	haematopoietic_and_lymphoid_tissue	COSMIC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P776S	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.6752
p.K784T	HCT-15	large_intestine	COSMIC	RVGMYLE	LIG_APCC_ABBAyCdc20_2	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RVGMYLE

Degron related mutations and impact score

Drug responses associated with DLC1 mutations

All proteins holding degron of RVGMYLE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96QB1	Rho GTPase-activating protein 7	LIG_APCC_ABBAyCdc20_2	771:777	RVGMYLE	APC,CDC20,FZR1	0.8802	More...