DegronMD

Uniprot ID: Q96QB1

Source protein: Rho GTPase-activating protein 7

Source gene: DLC1

Class: DEG_SPOP_SBC_1

Location: 624:628

E3 ligase: SPOP

DEGRON score: 0.9791

ASA_SCORE: 67.24

COIL: 0.7676

CONS_SCORE: 0.3988

DSS_SCORE: 0.4533

HELIX: 0.1006

FCONS_SCORE: 1.1256

RIG_SCORE: 0.7237

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P616H	TCGA-56-8083	LUSC	TCGA	VCSSS	DEG_SPOP_SBC_1	0.1111
p.P616H	DO223723	LUSC	ICGC	VCSSS	DEG_SPOP_SBC_1	0.1111
p.G638V	TCGA-AA-3986	COAD	TCGA	VCSSS	DEG_SPOP_SBC_1	0.0556
p.R617Q	TCGA-BG-A0VW	UCEC	TCGA	VCSSS	DEG_SPOP_SBC_1	0.1389
p.R617Q	SIDM01664	Prostate Carcinoma	GDSC	VCSSS	DEG_SPOP_SBC_1	0.1389
p.G638D	TCGA-BR-4357	STAD	TCGA	VCSSS	DEG_SPOP_SBC_1	0.0556
p.G638D	DO38241	STAD	ICGC	VCSSS	DEG_SPOP_SBC_1	0.0556
p.S620F	TCGA-D3-A3MV	SKCM	TCGA	VCSSS	DEG_SPOP_SBC_1	0.2222
p.S620F	TCGA-D3-A5GO	SKCM	TCGA	VCSSS	DEG_SPOP_SBC_1	0.2222
p.S620F	SIDM00974	Melanoma	GDSC	VCSSS	DEG_SPOP_SBC_1	0.2222
p.S620F	ACH-002207	Skin Cancer	CCLE	VCSSS	DEG_SPOP_SBC_1	0.2222
p.S620F	WM35	skin	COSMIC	VCSSS	DEG_SPOP_SBC_1	0.2222
p.A614T	TCGA-GU-AATO	BLCA	TCGA	VCSSS	DEG_SPOP_SBC_1	0.0556
p.V624I	TCGA-MT-A51X	HNSC	TCGA	VCSSS	DEG_SPOP_SBC_1	0.7076
p.V624I	DO44441	HNSC	ICGC	VCSSS	DEG_SPOP_SBC_1	0.7076
p.G620C	DO47299	SKCM	ICGC	VCSSS	DEG_SPOP_SBC_1	0.2222
p.P631S	DO42023	UCEC	ICGC	VCSSS	DEG_SPOP_SBC_1	0.25
p.V621I	SIDM00216	Colorectal Carcinoma	GDSC	VCSSS	DEG_SPOP_SBC_1	0.25
p.V621I	ACH-000989	Colon/Colorectal Cancer	CCLE	VCSSS	DEG_SPOP_SBC_1	0.25
p.V621I	SNU-175	large_intestine	COSMIC	VCSSS	DEG_SPOP_SBC_1	0.25
p.I622V	SIDM00652	Small Cell Lung Carcinoma	GDSC	VCSSS	DEG_SPOP_SBC_1	0.2778
p.I622V	ACH-000780	Lung Cancer	CCLE	VCSSS	DEG_SPOP_SBC_1	0.2778
p.I622V	NCI-H1105	lung	COSMIC	VCSSS	DEG_SPOP_SBC_1	0.2778
p.S626F	SIDM00638	Cervical Carcinoma	GDSC	VCSSS	DEG_SPOP_SBC_1	0.7982
p.S626F	ACH-001360	Cervical Cancer	CCLE	VCSSS	DEG_SPOP_SBC_1	0.7982
p.S626F	MS751	cervix	COSMIC	VCSSS	DEG_SPOP_SBC_1	0.7982
p.V622A	HCT-116	large_intestine	COSMIC	VCSSS	DEG_SPOP_SBC_1	0.2778
p.A620D	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	VCSSS	DEG_SPOP_SBC_1	0.2222
p.E628G	CCK-81	large_intestine	COSMIC	VCSSS	DEG_SPOP_SBC_1	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N1W1	Rho guanine nucleotide exchange factor 28	DEG_SPOP_SBC_1	577:581	VCSSS	SPOP	0.9989	More...
Q96QB1	Rho GTPase-activating protein 7	DEG_SPOP_SBC_1	624:628	VCSSS	SPOP	0.9791	More...
Q9C0D2	Centrosomal protein of 295 kDa	DEG_SPOP_SBC_1	1546:1550	VCSSS	SPOP	0.8548	More...
Q9NWQ4	G patch domain-containing protein 2-like	DEG_SPOP_SBC_1	226:230	VCSSS	SPOP	0.9077	More...
Q9ULJ3	Zinc finger and BTB domain-containing protein 21	DEG_SPOP_SBC_1	282:286	VCSSS	SPOP	0.9458	More...
Q9Y6Q6	Tumor necrosis factor receptor superfamily member 11A	DEG_SPOP_SBC_1	193:197	VCSSS	SPOP	0.5093	More...
O15016	Tripartite motif-containing protein 66	DEG_SPOP_SBC_1	315:319	VCSSS	SPOP	0.632	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VCSSS

Degron related mutations and impact score

Drug responses associated with DLC1 mutations

All proteins holding degron of VCSSS