DegronMD - Q9NWQ4(GPATCH2L)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G240W	TCGA-46-3767	LUSC	TCGA	VCSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.0556
p.G240W	DO26650	LUSC	ICGC	VCSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.0556
p.G233V	TCGA-49-6767	LUAD	TCGA	VCSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.25
p.G233V	DO23586	LUAD	ICGC	VCSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.25
p.R170S	TCGA-55-6979	LUAD	TCGA	WKENT	DEG_APCC_KENBOX_2	171:175	Mutation rewiring degron network	0.3056
p.R170S	TCGA-55-6979	LUAD	TCGA	PWTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.1667
p.R170S	DO24110	LUAD	ICGC	WKENT	DEG_APCC_KENBOX_2	171:175	Mutation rewiring degron network	0.3056
p.R170S	DO24110	LUAD	ICGC	PWTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.1667
p.Q166H	TCGA-55-7994	LUAD	TCGA	WKENT	DEG_APCC_KENBOX_2	171:175	Mutation rewiring degron network	0.1944
p.Q166H	TCGA-55-7994	LUAD	TCGA	PWTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.0556
p.Q166H	DO45311	LUAD	ICGC	WKENT	DEG_APCC_KENBOX_2	171:175	Mutation rewiring degron network	0.1944
p.Q166H	DO45311	LUAD	ICGC	PWTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.0556
p.S228I	TCGA-A5-A0G1	UCEC	TCGA	VCSSS	DEG_SPOP_SBC_1	226:230	Mutation altering degron motif	0.7341
p.S228I	DO42472	UCEC	ICGC	VCSSS	DEG_SPOP_SBC_1	226:230	Mutation altering degron motif	0.7341
p.K161E	TCGA-AB-2826	LAML	TCGA	WKENT	DEG_APCC_KENBOX_2	171:175	Mutation substituting flanking lysine	0.1667
p.K161E	DO21833	LAML	ICGC	WKENT	DEG_APCC_KENBOX_2	171:175	Mutation substituting flanking lysine	0.1667
p.R167H	TCGA-AJ-A3EL	UCEC	TCGA	WKENT	DEG_APCC_KENBOX_2	171:175	Mutation rewiring degron network	0.2222
p.R167H	TCGA-AJ-A3EL	UCEC	TCGA	PWTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.0833
p.R167H	DO41542	UCEC	ICGC	WKENT	DEG_APCC_KENBOX_2	171:175	Mutation rewiring degron network	0.2222
p.R167H	DO41542	UCEC	ICGC	PWTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.0833
p.S224R	TCGA-CV-5432	HNSC	TCGA	VCSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.2778
p.S224R	DO14343	HNSC	ICGC	VCSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.2778
p.E173D	DO48446	BLCA	ICGC	WKENT	DEG_APCC_KENBOX_2	171:175	Mutation altering degron motif	0.6758
p.V226M	DO233888	GACA	ICGC	VCSSS	DEG_SPOP_SBC_1	226:230	Mutation altering degron motif	0.7208
p.S224I	DO228948	LICA	ICGC	VCSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.2778
p.S224I	DO229027	LICA	ICGC	VCSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.2778
p.S229I	DO228974	LICA	ICGC	VCSSS	DEG_SPOP_SBC_1	226:230	Mutation altering degron motif	0.7341
p.P176S	DO222843	MELA	ICGC	PWTSS	DEG_SPOP_SBC_1	176:180	Mutation altering degron motif	0.6752
p.S219L	DO47092	RECA	ICGC	VCSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1389
p.D238G	SIDM00155	Head and Neck Carcinoma	GDSC	VCSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1111
p.D238G	ACH-002296	Head and Neck Cancer	CCLE	VCSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1111
p.D238G	PCI-38	upper aerodigestive tract	COSMIC	VCSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GPATCH2L

UniProt ID: Q9NWQ4

Entrez ID: 55668

Protein name: G patch domain-containing protein 2-like

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GPATCH2L in