DegronMD

Uniprot ID: Q9NWQ4

Source protein: G patch domain-containing protein 2-like

Source gene: GPATCH2L

Class: DEG_SPOP_SBC_1

Location: 226:230

E3 ligase: SPOP

DEGRON score: 0.9077

ASA_SCORE: 80.58

COIL: 0.8924

CONS_SCORE: 0.7104

DSS_SCORE: 0.4915

HELIX: 0.0668

FCONS_SCORE: 0.9638

RIG_SCORE: 0.6683

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G240W	TCGA-46-3767	LUSC	TCGA	VCSSS	DEG_SPOP_SBC_1	0.0556
p.G240W	DO26650	LUSC	ICGC	VCSSS	DEG_SPOP_SBC_1	0.0556
p.G233V	TCGA-49-6767	LUAD	TCGA	VCSSS	DEG_SPOP_SBC_1	0.25
p.G233V	DO23586	LUAD	ICGC	VCSSS	DEG_SPOP_SBC_1	0.25
p.S228I	TCGA-A5-A0G1	UCEC	TCGA	VCSSS	DEG_SPOP_SBC_1	0.7341
p.S228I	DO42472	UCEC	ICGC	VCSSS	DEG_SPOP_SBC_1	0.7341
p.S224R	TCGA-CV-5432	HNSC	TCGA	VCSSS	DEG_SPOP_SBC_1	0.2778
p.S224R	DO14343	HNSC	ICGC	VCSSS	DEG_SPOP_SBC_1	0.2778
p.V226M	DO233888	GACA	ICGC	VCSSS	DEG_SPOP_SBC_1	0.7208
p.S224I	DO228948	LICA	ICGC	VCSSS	DEG_SPOP_SBC_1	0.2778
p.S224I	DO229027	LICA	ICGC	VCSSS	DEG_SPOP_SBC_1	0.2778
p.S229I	DO228974	LICA	ICGC	VCSSS	DEG_SPOP_SBC_1	0.7341
p.S219L	DO47092	RECA	ICGC	VCSSS	DEG_SPOP_SBC_1	0.1389
p.D238G	SIDM00155	Head and Neck Carcinoma	GDSC	VCSSS	DEG_SPOP_SBC_1	0.1111
p.D238G	ACH-002296	Head and Neck Cancer	CCLE	VCSSS	DEG_SPOP_SBC_1	0.1111
p.D238G	PCI-38	upper_aerodigestive_tract	COSMIC	VCSSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N1W1	Rho guanine nucleotide exchange factor 28	DEG_SPOP_SBC_1	577:581	VCSSS	SPOP	0.9989	More...
Q96QB1	Rho GTPase-activating protein 7	DEG_SPOP_SBC_1	624:628	VCSSS	SPOP	0.9791	More...
Q9C0D2	Centrosomal protein of 295 kDa	DEG_SPOP_SBC_1	1546:1550	VCSSS	SPOP	0.8548	More...
Q9NWQ4	G patch domain-containing protein 2-like	DEG_SPOP_SBC_1	226:230	VCSSS	SPOP	0.9077	More...
Q9ULJ3	Zinc finger and BTB domain-containing protein 21	DEG_SPOP_SBC_1	282:286	VCSSS	SPOP	0.9458	More...
Q9Y6Q6	Tumor necrosis factor receptor superfamily member 11A	DEG_SPOP_SBC_1	193:197	VCSSS	SPOP	0.5093	More...
O15016	Tripartite motif-containing protein 66	DEG_SPOP_SBC_1	315:319	VCSSS	SPOP	0.632	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons