DegronMD

Uniprot ID: Q9C0D2

Source protein: Centrosomal protein of 295 kDa

Source gene: CEP295

Class: DEG_SPOP_SBC_1

Location: 1546:1550

E3 ligase: SPOP

DEGRON score: 0.8548

ASA_SCORE: 78.54

COIL: 0.8434

CONS_SCORE: 0.4036

DSS_SCORE: 0.3415

HELIX: 0.1062

FCONS_SCORE: 0.9588

RIG_SCORE: 0.7052

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1560Y	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	VCSSS	DEG_SPOP_SBC_1	0.0556
p.S1560Y	TE-15	oesophagus	COSMIC	VCSSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N1W1	Rho guanine nucleotide exchange factor 28	DEG_SPOP_SBC_1	577:581	VCSSS	SPOP	0.9989	More...
Q96QB1	Rho GTPase-activating protein 7	DEG_SPOP_SBC_1	624:628	VCSSS	SPOP	0.9791	More...
Q9C0D2	Centrosomal protein of 295 kDa	DEG_SPOP_SBC_1	1546:1550	VCSSS	SPOP	0.8548	More...
Q9NWQ4	G patch domain-containing protein 2-like	DEG_SPOP_SBC_1	226:230	VCSSS	SPOP	0.9077	More...
Q9ULJ3	Zinc finger and BTB domain-containing protein 21	DEG_SPOP_SBC_1	282:286	VCSSS	SPOP	0.9458	More...
Q9Y6Q6	Tumor necrosis factor receptor superfamily member 11A	DEG_SPOP_SBC_1	193:197	VCSSS	SPOP	0.5093	More...
O15016	Tripartite motif-containing protein 66	DEG_SPOP_SBC_1	315:319	VCSSS	SPOP	0.632	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons