DegronMD - Q8N1W1(ARHGEF28)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S590L	TCGA-76-6285	GBM	TCGA	VCSSS	DEG_SPOP_SBC_1	577:581	Mutation blocking phosphorylation signal	0.5278
p.S590L	TCGA-VQ-A91K	STAD	TCGA	VCSSS	DEG_SPOP_SBC_1	577:581	Mutation blocking phosphorylation signal	0.5278
p.S590L	DO11962	GBM	ICGC	VCSSS	DEG_SPOP_SBC_1	577:581	Mutation blocking phosphorylation signal	0.5278
p.S590L	DO51785	STAD	ICGC	VCSSS	DEG_SPOP_SBC_1	577:581	Mutation blocking phosphorylation signal	0.5278
p.E583D	TCGA-78-7147	LUAD	TCGA	VCSSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.2778
p.E583D	DO24527	LUAD	ICGC	VCSSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.2778
p.T1659M	TCGA-EO-A22T	UCEC	TCGA	PTPHDS	DEG_SCF_FBW7_1	1659:1664	Mutation altering degron motif	0.7423
p.T1659M	DO9876	COAD	ICGC	PTPHDS	DEG_SCF_FBW7_1	1659:1664	Mutation altering degron motif	0.7423
p.T1659M	DO42320	UCEC	ICGC	PTPHDS	DEG_SCF_FBW7_1	1659:1664	Mutation altering degron motif	0.7423
p.T1659M	SIDM00282	Colorectal Carcinoma	GDSC	PTPHDS	DEG_SCF_FBW7_1	1659:1664	Mutation altering degron motif	0.7423
p.T1659M	CW-2	large intestine	COSMIC	PTPHDS	DEG_SCF_FBW7_1	1659:1664	Mutation altering degron motif	0.7423
p.S1657T	DO225012	BRCA	ICGC	PTPHDS	DEG_SCF_FBW7_1	1659:1664	Mutation rewiring degron network	0.2778
p.P1664L	DO227999	COCA	ICGC	PTPHDS	DEG_SCF_FBW7_1	1659:1664	Mutation altering degron motif	0.7582
p.P1664L	DO228941	LICA	ICGC	PTPHDS	DEG_SCF_FBW7_1	1659:1664	Mutation altering degron motif	0.7582
p.P1664L	DO230993	LUSC	ICGC	PTPHDS	DEG_SCF_FBW7_1	1659:1664	Mutation altering degron motif	0.7582
p.R585K	DO229013	COCA	ICGC	VCSSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.2222
p.R585K	DO229003	COCA	ICGC	VCSSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.2222
p.R585K	DO229047	LICA	ICGC	VCSSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.2222
p.R585K	DO230529	LUSC	ICGC	VCSSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.2222
p.R585K	DO230993	LUSC	ICGC	VCSSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.2222
p.R585K	DO230990	LUSC	ICGC	VCSSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.2222
p.R585K	DO231007	LUSC	ICGC	VCSSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.2222
p.R570L	DO229022	LICA	ICGC	VCSSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.1389
p.A586S	DO229022	LICA	ICGC	VCSSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.1944
p.C1656F	DO229032	LICA	ICGC	PTPHDS	DEG_SCF_FBW7_1	1659:1664	Mutation rewiring degron network	0.25
p.L575F	SIDM00084	Glioblastoma	GDSC	VCSSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.2778
p.L575F	SIDM01109	Other Sarcomas	GDSC	VCSSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.2778
p.L575F	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	VCSSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.2778
p.S1672T	SIDM00232	Kidney Carcinoma	GDSC	PTPHDS	DEG_SCF_FBW7_1	1659:1664	Mutation rewiring degron network	0.1111
p.S1672T	NCC021	kidney	COSMIC	PTPHDS	DEG_SCF_FBW7_1	1659:1664	Mutation rewiring degron network	0.1111
p.R573C	SIDM00447	B-Lymphoblastic Leukemia	GDSC	VCSSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.2222
p.R573C	SIDM00136	Colorectal Carcinoma	GDSC	VCSSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.2222
p.R573C	SIDM00861	Ovarian Carcinoma	GDSC	VCSSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.2222
p.K568R	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	VCSSS	DEG_SPOP_SBC_1	577:581	Mutation substituting flanking lysine	0.1944
p.K568R	ACH-000888	Lung Cancer	CCLE	VCSSS	DEG_SPOP_SBC_1	577:581	Mutation substituting flanking lysine	0.1944
p.K568R	NCI-H1793	lung	COSMIC	VCSSS	DEG_SPOP_SBC_1	577:581	Mutation substituting flanking lysine	0.1944
p.A1673V	ACH-000974	Endometrial/Uterine Cancer	CCLE	PTPHDS	DEG_SCF_FBW7_1	1659:1664	Mutation rewiring degron network	0.0833
p.T579M	CW-2	large intestine	COSMIC	VCSSS	DEG_SPOP_SBC_1	577:581	Mutation altering degron motif	0.7423
p.R1668H	OCUB-M	breast	COSMIC	PTPHDS	DEG_SCF_FBW7_1	1659:1664	Mutation rewiring degron network	0.2222
p.H591R	NCI-H2141	lung	COSMIC	VCSSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.0556

Kaplan plot for ARHGEF28 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGEF28

UniProt ID: Q8N1W1

Entrez ID: 64283

Protein name: Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ARHGEF28 in