DegronMD

Uniprot ID: Q8N1W1

Source protein: Rho guanine nucleotide exchange factor 28

Source gene: ARHGEF28

Class: DEG_SCF_FBW7_1

Location: 1659:1664

E3 ligase: FBXW7

DEGRON score: 0.8312

ASA_SCORE: 88.15

COIL: 0.917

CONS_SCORE: 0.2905

DSS_SCORE: 0.7931

HELIX: 0.0543

FCONS_SCORE: 1.054

RIG_SCORE: 0.5415

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1659M	TCGA-EO-A22T	UCEC	TCGA	PTPHDS	DEG_SCF_FBW7_1	0.7423
p.T1659M	DO9876	COAD	ICGC	PTPHDS	DEG_SCF_FBW7_1	0.7423
p.T1659M	DO42320	UCEC	ICGC	PTPHDS	DEG_SCF_FBW7_1	0.7423
p.T1659M	SIDM00282	Colorectal Carcinoma	GDSC	PTPHDS	DEG_SCF_FBW7_1	0.7423
p.T1659M	CW-2	large_intestine	COSMIC	PTPHDS	DEG_SCF_FBW7_1	0.7423
p.S1657T	DO225012	BRCA	ICGC	PTPHDS	DEG_SCF_FBW7_1	0.2778
p.P1664L	DO227999	COCA	ICGC	PTPHDS	DEG_SCF_FBW7_1	0.7582
p.P1664L	DO228941	LICA	ICGC	PTPHDS	DEG_SCF_FBW7_1	0.7582
p.P1664L	DO230993	LUSC	ICGC	PTPHDS	DEG_SCF_FBW7_1	0.7582
p.C1656F	DO229032	LICA	ICGC	PTPHDS	DEG_SCF_FBW7_1	0.25
p.S1672T	SIDM00232	Kidney Carcinoma	GDSC	PTPHDS	DEG_SCF_FBW7_1	0.1111
p.S1672T	NCC021	kidney	COSMIC	PTPHDS	DEG_SCF_FBW7_1	0.1111
p.A1673V	ACH-000974	Endometrial/Uterine Cancer	CCLE	PTPHDS	DEG_SCF_FBW7_1	0.0833
p.R1668H	OCUB-M	breast	COSMIC	PTPHDS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N1W1	Rho guanine nucleotide exchange factor 28	DEG_SCF_FBW7_1	1659:1664	PTPHDS	FBXW7	0.8312	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons