DegronMD

Uniprot ID: Q8N1W1

Source protein: Rho guanine nucleotide exchange factor 28

Source gene: ARHGEF28

Class: DEG_SPOP_SBC_1

Location: 577:581

E3 ligase: SPOP

DEGRON score: 0.9989

ASA_SCORE: 70.62

COIL: 0.7774

CONS_SCORE: 0.3029

DSS_SCORE: 0.344

HELIX: 0.163

FCONS_SCORE: 1.0112

RIG_SCORE: 0.7347

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S590L	TCGA-76-6285	GBM	TCGA	VCSSS	DEG_SPOP_SBC_1	0.5278
p.S590L	TCGA-VQ-A91K	STAD	TCGA	VCSSS	DEG_SPOP_SBC_1	0.5278
p.S590L	DO11962	GBM	ICGC	VCSSS	DEG_SPOP_SBC_1	0.5278
p.S590L	DO51785	STAD	ICGC	VCSSS	DEG_SPOP_SBC_1	0.5278
p.E583D	TCGA-78-7147	LUAD	TCGA	VCSSS	DEG_SPOP_SBC_1	0.2778
p.E583D	DO24527	LUAD	ICGC	VCSSS	DEG_SPOP_SBC_1	0.2778
p.R585K	DO229013	COCA	ICGC	VCSSS	DEG_SPOP_SBC_1	0.2222
p.R585K	DO229003	COCA	ICGC	VCSSS	DEG_SPOP_SBC_1	0.2222
p.R585K	DO229047	LICA	ICGC	VCSSS	DEG_SPOP_SBC_1	0.2222
p.R585K	DO230529	LUSC	ICGC	VCSSS	DEG_SPOP_SBC_1	0.2222
p.R585K	DO230993	LUSC	ICGC	VCSSS	DEG_SPOP_SBC_1	0.2222
p.R585K	DO230990	LUSC	ICGC	VCSSS	DEG_SPOP_SBC_1	0.2222
p.R585K	DO231007	LUSC	ICGC	VCSSS	DEG_SPOP_SBC_1	0.2222
p.R570L	DO229022	LICA	ICGC	VCSSS	DEG_SPOP_SBC_1	0.1389
p.A586S	DO229022	LICA	ICGC	VCSSS	DEG_SPOP_SBC_1	0.1944
p.L575F	SIDM00084	Glioblastoma	GDSC	VCSSS	DEG_SPOP_SBC_1	0.2778
p.L575F	SIDM01109	Other Sarcomas	GDSC	VCSSS	DEG_SPOP_SBC_1	0.2778
p.L575F	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	VCSSS	DEG_SPOP_SBC_1	0.2778
p.R573C	SIDM00447	B-Lymphoblastic Leukemia	GDSC	VCSSS	DEG_SPOP_SBC_1	0.2222
p.R573C	SIDM00136	Colorectal Carcinoma	GDSC	VCSSS	DEG_SPOP_SBC_1	0.2222
p.R573C	SIDM00861	Ovarian Carcinoma	GDSC	VCSSS	DEG_SPOP_SBC_1	0.2222
p.K568R	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	VCSSS	DEG_SPOP_SBC_1	0.1944
p.K568R	ACH-000888	Lung Cancer	CCLE	VCSSS	DEG_SPOP_SBC_1	0.1944
p.K568R	NCI-H1793	lung	COSMIC	VCSSS	DEG_SPOP_SBC_1	0.1944
p.T579M	CW-2	large_intestine	COSMIC	VCSSS	DEG_SPOP_SBC_1	0.7423
p.H591R	NCI-H2141	lung	COSMIC	VCSSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N1W1	Rho guanine nucleotide exchange factor 28	DEG_SPOP_SBC_1	577:581	VCSSS	SPOP	0.9989	More...
Q96QB1	Rho GTPase-activating protein 7	DEG_SPOP_SBC_1	624:628	VCSSS	SPOP	0.9791	More...
Q9C0D2	Centrosomal protein of 295 kDa	DEG_SPOP_SBC_1	1546:1550	VCSSS	SPOP	0.8548	More...
Q9NWQ4	G patch domain-containing protein 2-like	DEG_SPOP_SBC_1	226:230	VCSSS	SPOP	0.9077	More...
Q9ULJ3	Zinc finger and BTB domain-containing protein 21	DEG_SPOP_SBC_1	282:286	VCSSS	SPOP	0.9458	More...
Q9Y6Q6	Tumor necrosis factor receptor superfamily member 11A	DEG_SPOP_SBC_1	193:197	VCSSS	SPOP	0.5093	More...
O15016	Tripartite motif-containing protein 66	DEG_SPOP_SBC_1	315:319	VCSSS	SPOP	0.632	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons