DegronMD

Uniprot ID: O15016

Source protein: Tripartite motif-containing protein 66

Source gene: TRIM66

Class: DEG_SPOP_SBC_1

Location: 315:319

E3 ligase: SPOP

DEGRON score: 0.632

ASA_SCORE: 81.82

COIL: 0.8938

CONS_SCORE: 0.2609

DSS_SCORE: 0.0888

HELIX: 0.047

FCONS_SCORE: 0.6084

RIG_SCORE: 0.6726

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A312T	TCGA-AJ-A2QO	UCEC	TCGA	VCSSS	DEG_SPOP_SBC_1	0.25
p.A312T	DO23284	LINC	ICGC	VCSSS	DEG_SPOP_SBC_1	0.25
p.A312T	DO42177	UCEC	ICGC	VCSSS	DEG_SPOP_SBC_1	0.25
p.C314Y	TCGA-AJ-A3BH	UCEC	TCGA	VCSSS	DEG_SPOP_SBC_1	0.3056
p.C314Y	DO41638	UCEC	ICGC	VCSSS	DEG_SPOP_SBC_1	0.3056
p.H322R	DO222990	BTCA	ICGC	VCSSS	DEG_SPOP_SBC_1	0.25
p.H322R	DO229013	COCA	ICGC	VCSSS	DEG_SPOP_SBC_1	0.25
p.H322R	DO229016	COCA	ICGC	VCSSS	DEG_SPOP_SBC_1	0.25
p.H322R	DO229005	COCA	ICGC	VCSSS	DEG_SPOP_SBC_1	0.25
p.H322R	DO229489	LAML	ICGC	VCSSS	DEG_SPOP_SBC_1	0.25
p.H322R	DO228946	LICA	ICGC	VCSSS	DEG_SPOP_SBC_1	0.25
p.H322R	DO230929	LUSC	ICGC	VCSSS	DEG_SPOP_SBC_1	0.25
p.P311S	DO222775	MELA	ICGC	VCSSS	DEG_SPOP_SBC_1	0.2222
p.C319Y	DO48941	PBCA	ICGC	VCSSS	DEG_SPOP_SBC_1	0.7087
p.N312T	SIDM00875	Breast Carcinoma	GDSC	VCSSS	DEG_SPOP_SBC_1	0.25
p.N312T	SIDM00954	Breast Carcinoma	GDSC	VCSSS	DEG_SPOP_SBC_1	0.25
p.A312V	JHOS-2	ovary	COSMIC	VCSSS	DEG_SPOP_SBC_1	0.25
p.A312V	Sarc9371	bone	COSMIC	VCSSS	DEG_SPOP_SBC_1	0.25
p.A312V	BFTC-909	kidney	COSMIC	VCSSS	DEG_SPOP_SBC_1	0.25
p.A312V	NCI-SNU-16	stomach	COSMIC	VCSSS	DEG_SPOP_SBC_1	0.25
p.A314V	JHOS-2	ovary	COSMIC	VCSSS	DEG_SPOP_SBC_1	0.3056
p.A314V	Sarc9371	bone	COSMIC	VCSSS	DEG_SPOP_SBC_1	0.3056
p.A314V	BFTC-909	kidney	COSMIC	VCSSS	DEG_SPOP_SBC_1	0.3056
p.A314V	NCI-SNU-16	stomach	COSMIC	VCSSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N1W1	Rho guanine nucleotide exchange factor 28	DEG_SPOP_SBC_1	577:581	VCSSS	SPOP	0.9989	More...
Q96QB1	Rho GTPase-activating protein 7	DEG_SPOP_SBC_1	624:628	VCSSS	SPOP	0.9791	More...
Q9C0D2	Centrosomal protein of 295 kDa	DEG_SPOP_SBC_1	1546:1550	VCSSS	SPOP	0.8548	More...
Q9NWQ4	G patch domain-containing protein 2-like	DEG_SPOP_SBC_1	226:230	VCSSS	SPOP	0.9077	More...
Q9ULJ3	Zinc finger and BTB domain-containing protein 21	DEG_SPOP_SBC_1	282:286	VCSSS	SPOP	0.9458	More...
Q9Y6Q6	Tumor necrosis factor receptor superfamily member 11A	DEG_SPOP_SBC_1	193:197	VCSSS	SPOP	0.5093	More...
O15016	Tripartite motif-containing protein 66	DEG_SPOP_SBC_1	315:319	VCSSS	SPOP	0.632	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons