DegronMD - O15016(TRIM66)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A312T	TCGA-AJ-A2QO	UCEC	TCGA	VCSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.25
p.A312T	DO23284	LINC	ICGC	VCSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.25
p.A312T	DO42177	UCEC	ICGC	VCSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.25
p.C314Y	TCGA-AJ-A3BH	UCEC	TCGA	VCSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.3056
p.C314Y	DO41638	UCEC	ICGC	VCSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.3056
p.E78Q	TCGA-AR-A24L	BRCA	TCGA	LKLFCE	LIG_APCC_ABBA_1	73:78	Mutation altering degron motif	0.6744
p.E78Q	DO3928	BRCA	ICGC	LKLFCE	LIG_APCC_ABBA_1	73:78	Mutation altering degron motif	0.6744
p.E78Q	ACH-001402	Cervical Cancer	CCLE	LKLFCE	LIG_APCC_ABBA_1	73:78	Mutation altering degron motif	0.6744
p.E78Q	SW756	cervix	COSMIC	LKLFCE	LIG_APCC_ABBA_1	73:78	Mutation altering degron motif	0.6744
p.M738T	TCGA-EO-A3KX	UCEC	TCGA	SGHTQAVPSL	DEG_COP1_1	741:750	Mutation rewiring degron network	0.25
p.L63F	DO225013	BRCA	ICGC	LKLFCE	LIG_APCC_ABBA_1	73:78	Mutation rewiring degron network	0.0556
p.L63F	DO52557	BRCA	ICGC	LKLFCE	LIG_APCC_ABBA_1	73:78	Mutation rewiring degron network	0.0556
p.H322R	DO222990	BTCA	ICGC	VCSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.25
p.H322R	DO229013	COCA	ICGC	VCSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.25
p.H322R	DO229016	COCA	ICGC	VCSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.25
p.H322R	DO229005	COCA	ICGC	VCSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.25
p.H322R	DO229489	LAML	ICGC	VCSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.25
p.H322R	DO228946	LICA	ICGC	VCSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.25
p.H322R	DO230929	LUSC	ICGC	VCSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.25
p.Q732P	DO229480	LAML	ICGC	SGHTQAVPSL	DEG_COP1_1	741:750	Mutation rewiring degron network	0.0833
p.N828K	DO229037	LICA	ICGC	VVSTS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.1111
p.A824G	DO229054	LICA	ICGC	VVSTS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.2222
p.H732Y	DO222647	MELA	ICGC	SGHTQAVPSL	DEG_COP1_1	741:750	Mutation rewiring degron network	0.0833
p.P311S	DO222775	MELA	ICGC	VCSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.2222
p.P759L	DO222721	MELA	ICGC	SGHTQAVPSL	DEG_COP1_1	741:750	Mutation rewiring degron network	0.0833
p.C319Y	DO48941	PBCA	ICGC	VCSSS	DEG_SPOP_SBC_1	315:319	Mutation altering degron motif	0.7087
p.S736N	DO232761	PBCA	ICGC	SGHTQAVPSL	DEG_COP1_1	741:750	Mutation rewiring degron network	0.1944
p.P826S	DO219871	SKCA	ICGC	VVSTS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.1667
p.A814V	DO38376	STAD	ICGC	VVSTS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.2778
p.A814V	DO43578	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.2778
p.M740T	DO219774	UCEC	ICGC	SGHTQAVPSL	DEG_COP1_1	741:750	Mutation rewiring degron network	0.3056
p.N828H	DO41488	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.1111
p.P754L	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	SGHTQAVPSL	DEG_COP1_1	741:750	Mutation rewiring degron network	0.2222
p.P754L	H9	haematopoietic and lymphoid tissue	COSMIC	SGHTQAVPSL	DEG_COP1_1	741:750	Mutation rewiring degron network	0.2222
p.P755A	SIDM01259	B-Lymphoblastic Leukemia	GDSC	SGHTQAVPSL	DEG_COP1_1	741:750	Mutation rewiring degron network	0.1944
p.P755A	GR-ST	haematopoietic and lymphoid tissue	COSMIC	SGHTQAVPSL	DEG_COP1_1	741:750	Mutation rewiring degron network	0.1944
p.N312T	SIDM00875	Breast Carcinoma	GDSC	VCSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.25
p.N312T	SIDM00954	Breast Carcinoma	GDSC	VCSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.25
p.D757N	SIDM00245	Small Cell Lung Carcinoma	GDSC	SGHTQAVPSL	DEG_COP1_1	741:750	Mutation rewiring degron network	0.1389
p.D757N	MS-1	lung	COSMIC	SGHTQAVPSL	DEG_COP1_1	741:750	Mutation rewiring degron network	0.1389
p.L750R	ACH-000639	Lung Cancer	CCLE	SGHTQAVPSL	DEG_COP1_1	741:750	Mutation altering degron motif	0.8428
p.L750R	NCI-H211	lung	COSMIC	SGHTQAVPSL	DEG_COP1_1	741:750	Mutation altering degron motif	0.8428
p.Q745R	ACH-000831	Endometrial/Uterine Cancer	CCLE	SGHTQAVPSL	DEG_COP1_1	741:750	Mutation altering degron motif	0.6218
p.A822T	ACH-000983	Leukemia	CCLE	VVSTS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.2778
p.A822T	KCL-22	haematopoietic and lymphoid tissue	COSMIC	VVSTS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.2778
p.C88Y	ACH-000985	Colon/Colorectal Cancer	CCLE	LKLFCE	LIG_APCC_ABBA_1	73:78	Mutation rewiring degron network	0.0556
p.C88Y	LS-411N	large intestine	COSMIC	LKLFCE	LIG_APCC_ABBA_1	73:78	Mutation rewiring degron network	0.0556
p.G816R	NCI-H1944	lung	COSMIC	VVSTS	DEG_SPOP_SBC_1	816:820	Mutation altering degron motif	0.7568
p.G816R	DMS-273	lung	COSMIC	VVSTS	DEG_SPOP_SBC_1	816:820	Mutation altering degron motif	0.7568
p.G816R	SCC-4	upper aerodigestive tract	COSMIC	VVSTS	DEG_SPOP_SBC_1	816:820	Mutation altering degron motif	0.7568
p.G816R	YMB-1-E	breast	COSMIC	VVSTS	DEG_SPOP_SBC_1	816:820	Mutation altering degron motif	0.7568
p.G816S	SNU-C2B	large intestine	COSMIC	VVSTS	DEG_SPOP_SBC_1	816:820	Mutation altering degron motif	0.6993
p.A312V	JHOS-2	ovary	COSMIC	VCSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.25
p.A312V	Sarc9371	bone	COSMIC	VCSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.25
p.A312V	BFTC-909	kidney	COSMIC	VCSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.25
p.A312V	NCI-SNU-16	stomach	COSMIC	VCSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.25
p.L748R	NCI-H211	lung	COSMIC	SGHTQAVPSL	DEG_COP1_1	741:750	Mutation altering degron motif	0.8428
p.T749P	HT	haematopoietic and lymphoid tissue	COSMIC	SGHTQAVPSL	DEG_COP1_1	741:750	Mutation altering degron motif	0.7031
p.A314V	JHOS-2	ovary	COSMIC	VCSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.3056
p.A314V	Sarc9371	bone	COSMIC	VCSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.3056
p.A314V	BFTC-909	kidney	COSMIC	VCSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.3056
p.A314V	NCI-SNU-16	stomach	COSMIC	VCSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.3056
p.A824V	COLO-320-HSR	large intestine	COSMIC	VVSTS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.2222
p.D818N	SNU-387	liver	COSMIC	VVSTS	DEG_SPOP_SBC_1	816:820	Mutation altering degron motif	0.6932

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRIM66

UniProt ID: O15016

Entrez ID: 9866

Protein name: Tripartite motif-containing protein 66

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRIM66 in