DegronMD

Uniprot ID: O15016

Source protein: Tripartite motif-containing protein 66

Source gene: TRIM66

Class: LIG_APCC_ABBA_1

Location: 73:78

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5402

ASA_SCORE: 39.6833

COIL: 0.2252

CONS_SCORE: 0.4699

DSS_SCORE: 0.0034

HELIX: 0.0197

FCONS_SCORE: 1.4568

RIG_SCORE: 0.9639

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E78Q	TCGA-AR-A24L	BRCA	TCGA	LKLFCE	LIG_APCC_ABBA_1	0.6744
p.E78Q	DO3928	BRCA	ICGC	LKLFCE	LIG_APCC_ABBA_1	0.6744
p.E78Q	ACH-001402	Cervical Cancer	CCLE	LKLFCE	LIG_APCC_ABBA_1	0.6744
p.E78Q	SW756	cervix	COSMIC	LKLFCE	LIG_APCC_ABBA_1	0.6744
p.L63F	DO225013	BRCA	ICGC	LKLFCE	LIG_APCC_ABBA_1	0.0556
p.L63F	DO52557	BRCA	ICGC	LKLFCE	LIG_APCC_ABBA_1	0.0556
p.C88Y	ACH-000985	Colon/Colorectal Cancer	CCLE	LKLFCE	LIG_APCC_ABBA_1	0.0556
p.C88Y	LS-411N	large_intestine	COSMIC	LKLFCE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15016	Tripartite motif-containing protein 66	LIG_APCC_ABBA_1	73:78	LKLFCE	APC,CDC20,FZR1	0.5402	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons