DegronMD

Uniprot ID: O15016

Source protein: Tripartite motif-containing protein 66

Source gene: TRIM66

Class: DEG_COP1_1

Location: 741:750

E3 ligase: COP1

DEGRON score: 0.9817

ASA_SCORE: 79.06

COIL: 0.8454

CONS_SCORE: 0.3889

DSS_SCORE: 0.5662

HELIX: 0.078

FCONS_SCORE: 0.8777

RIG_SCORE: 0.6499

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M738T	TCGA-EO-A3KX	UCEC	TCGA	SGHTQAVPSL	DEG_COP1_1	0.25
p.Q732P	DO229480	LAML	ICGC	SGHTQAVPSL	DEG_COP1_1	0.0833
p.H732Y	DO222647	MELA	ICGC	SGHTQAVPSL	DEG_COP1_1	0.0833
p.P759L	DO222721	MELA	ICGC	SGHTQAVPSL	DEG_COP1_1	0.0833
p.S736N	DO232761	PBCA	ICGC	SGHTQAVPSL	DEG_COP1_1	0.1944
p.M740T	DO219774	UCEC	ICGC	SGHTQAVPSL	DEG_COP1_1	0.3056
p.P754L	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	SGHTQAVPSL	DEG_COP1_1	0.2222
p.P754L	H9	haematopoietic_and_lymphoid_tissue	COSMIC	SGHTQAVPSL	DEG_COP1_1	0.2222
p.P755A	SIDM01259	B-Lymphoblastic Leukemia	GDSC	SGHTQAVPSL	DEG_COP1_1	0.1944
p.P755A	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	SGHTQAVPSL	DEG_COP1_1	0.1944
p.D757N	SIDM00245	Small Cell Lung Carcinoma	GDSC	SGHTQAVPSL	DEG_COP1_1	0.1389
p.D757N	MS-1	lung	COSMIC	SGHTQAVPSL	DEG_COP1_1	0.1389
p.L750R	ACH-000639	Lung Cancer	CCLE	SGHTQAVPSL	DEG_COP1_1	0.8428
p.L750R	NCI-H211	lung	COSMIC	SGHTQAVPSL	DEG_COP1_1	0.8428
p.Q745R	ACH-000831	Endometrial/Uterine Cancer	CCLE	SGHTQAVPSL	DEG_COP1_1	0.6218
p.L748R	NCI-H211	lung	COSMIC	SGHTQAVPSL	DEG_COP1_1	0.8428
p.T749P	HT	haematopoietic_and_lymphoid_tissue	COSMIC	SGHTQAVPSL	DEG_COP1_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15016	Tripartite motif-containing protein 66	DEG_COP1_1	741:750	SGHTQAVPSL	COP1	0.9817	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons