DegronMD

Uniprot ID: O15016

Source protein: Tripartite motif-containing protein 66

Source gene: TRIM66

Class: DEG_SPOP_SBC_1

Location: 816:820

E3 ligase: SPOP

DEGRON score: 0.6338

ASA_SCORE: 87.44

COIL: 0.9048

CONS_SCORE: 0.4287

DSS_SCORE: 0.4288

HELIX: 0.041

FCONS_SCORE: 1.0209

RIG_SCORE: 0.7451

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N828K	DO229037	LICA	ICGC	VVSTS	DEG_SPOP_SBC_1	0.1111
p.A824G	DO229054	LICA	ICGC	VVSTS	DEG_SPOP_SBC_1	0.2222
p.P826S	DO219871	SKCA	ICGC	VVSTS	DEG_SPOP_SBC_1	0.1667
p.A814V	DO38376	STAD	ICGC	VVSTS	DEG_SPOP_SBC_1	0.2778
p.A814V	DO43578	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	0.2778
p.N828H	DO41488	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	0.1111
p.A822T	ACH-000983	Leukemia	CCLE	VVSTS	DEG_SPOP_SBC_1	0.2778
p.A822T	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	VVSTS	DEG_SPOP_SBC_1	0.2778
p.G816R	NCI-H1944	lung	COSMIC	VVSTS	DEG_SPOP_SBC_1	0.7568
p.G816R	DMS-273	lung	COSMIC	VVSTS	DEG_SPOP_SBC_1	0.7568
p.G816R	SCC-4	upper_aerodigestive_tract	COSMIC	VVSTS	DEG_SPOP_SBC_1	0.7568
p.G816R	YMB-1-E	breast	COSMIC	VVSTS	DEG_SPOP_SBC_1	0.7568
p.G816S	SNU-C2B	large_intestine	COSMIC	VVSTS	DEG_SPOP_SBC_1	0.6993
p.A824V	COLO-320-HSR	large_intestine	COSMIC	VVSTS	DEG_SPOP_SBC_1	0.2222
p.D818N	SNU-387	liver	COSMIC	VVSTS	DEG_SPOP_SBC_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_SPOP_SBC_1	231:235	VVSTS	SPOP	0.8956	More...
O95235	Kinesin-like protein KIF20A	DEG_SPOP_SBC_1	45:49	VVSTS	SPOP	0.9985	More...
O95600	Krueppel-like factor 8	DEG_SPOP_SBC_1	121:125	VVSTS	SPOP	0.8645	More...
P23469	Receptor-type tyrosine-protein phosphatase epsilon	DEG_SPOP_SBC_1	78:82	VVSTS	SPOP	0.6754	More...
P51795	H	DEG_SPOP_SBC_1	724:728	VVSTS	SPOP	0.9829	More...
Q13422	DNA-binding protein Ikaros	DEG_SPOP_SBC_1	451:455	VVSTS	SPOP	0.7186	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1171:1175	VVSTS	SPOP	0.7463	More...
Q9H7D0	Dedicator of cytokinesis protein 5	DEG_SPOP_SBC_1	1679:1683	VVSTS	SPOP	0.9974	More...
O15016	Tripartite motif-containing protein 66	DEG_SPOP_SBC_1	816:820	VVSTS	SPOP	0.6338	More...
Q96BU1	S100P-binding protein	DEG_SPOP_SBC_1	270:274	VVSTS	SPOP	0.9689	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons