DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VVSTS
Uniprot ID:
Q96BU1
Source protein:
S100P-binding protein
Source gene:
S100PBP
Class:
DEG_SPOP_SBC_1
Location:
270:274
E3 ligase:
SPOP
DEGRON score:
0.9689
ASA_SCORE:
70
COIL:
0.7152
CONS_SCORE:
0.7846
DSS_SCORE:
0.5119
HELIX:
0.0664
FCONS_SCORE:
1.1626
RIG_SCORE:
0.7037
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.N282K
TCGA-06-1802
GBM
TCGA
VVSTS
DEG_SPOP_SBC_1
0.1111
p.N281K
DO12100
GBM
ICGC
VVSTS
DEG_SPOP_SBC_1
0.1389
Drug responses associated with S100PBP mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VVSTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A4UGR9
Xin actin-binding repeat-containing protein 2
DEG_SPOP_SBC_1
231:235
VVSTS
SPOP
0.8956
More...
O95235
Kinesin-like protein KIF20A
DEG_SPOP_SBC_1
45:49
VVSTS
SPOP
0.9985
More...
O95600
Krueppel-like factor 8
DEG_SPOP_SBC_1
121:125
VVSTS
SPOP
0.8645
More...
P23469
Receptor-type tyrosine-protein phosphatase epsilon
DEG_SPOP_SBC_1
78:82
VVSTS
SPOP
0.6754
More...
P51795
H
DEG_SPOP_SBC_1
724:728
VVSTS
SPOP
0.9829
More...
Q13422
DNA-binding protein Ikaros
DEG_SPOP_SBC_1
451:455
VVSTS
SPOP
0.7186
More...
Q6P4R8
Nuclear factor related to kappa-B-binding protein
DEG_SPOP_SBC_1
1171:1175
VVSTS
SPOP
0.7463
More...
Q9H7D0
Dedicator of cytokinesis protein 5
DEG_SPOP_SBC_1
1679:1683
VVSTS
SPOP
0.9974
More...
O15016
Tripartite motif-containing protein 66
DEG_SPOP_SBC_1
816:820
VVSTS
SPOP
0.6338
More...
Q96BU1
S100P-binding protein
DEG_SPOP_SBC_1
270:274
VVSTS
SPOP
0.9689
More...