DegronMD

Uniprot ID: Q9H7D0

Source protein: Dedicator of cytokinesis protein 5

Source gene: DOCK5

Class: DEG_SPOP_SBC_1

Location: 1679:1683

E3 ligase: SPOP

DEGRON score: 0.9974

ASA_SCORE: 103.44

COIL: 0.9738

CONS_SCORE: 0.2203

DSS_SCORE: 0.4679

HELIX: 0.0132

FCONS_SCORE: 0.9168

RIG_SCORE: 0.6597

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1669S	TCGA-AO-A0J5	BRCA	TCGA	VVSTS	DEG_SPOP_SBC_1	0.0556
p.R1669S	DO1429	BRCA	ICGC	VVSTS	DEG_SPOP_SBC_1	0.0556
p.T1682I	TCGA-PK-A5HB	ACC	TCGA	VVSTS	DEG_SPOP_SBC_1	0.7078
p.T1682S	DO233271	GACA	ICGC	VVSTS	DEG_SPOP_SBC_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_SPOP_SBC_1	231:235	VVSTS	SPOP	0.8956	More...
O95235	Kinesin-like protein KIF20A	DEG_SPOP_SBC_1	45:49	VVSTS	SPOP	0.9985	More...
O95600	Krueppel-like factor 8	DEG_SPOP_SBC_1	121:125	VVSTS	SPOP	0.8645	More...
P23469	Receptor-type tyrosine-protein phosphatase epsilon	DEG_SPOP_SBC_1	78:82	VVSTS	SPOP	0.6754	More...
P51795	H	DEG_SPOP_SBC_1	724:728	VVSTS	SPOP	0.9829	More...
Q13422	DNA-binding protein Ikaros	DEG_SPOP_SBC_1	451:455	VVSTS	SPOP	0.7186	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1171:1175	VVSTS	SPOP	0.7463	More...
Q9H7D0	Dedicator of cytokinesis protein 5	DEG_SPOP_SBC_1	1679:1683	VVSTS	SPOP	0.9974	More...
O15016	Tripartite motif-containing protein 66	DEG_SPOP_SBC_1	816:820	VVSTS	SPOP	0.6338	More...
Q96BU1	S100P-binding protein	DEG_SPOP_SBC_1	270:274	VVSTS	SPOP	0.9689	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons