DegronMD

Uniprot ID: O95235

Source protein: Kinesin-like protein KIF20A

Source gene: KIF20A

Class: DEG_SPOP_SBC_1

Location: 45:49

E3 ligase: SPOP

DEGRON score: 0.9985

ASA_SCORE: 83.02

COIL: 0.8804

CONS_SCORE: 0.403

DSS_SCORE: 0.3501

HELIX: 0.0792

FCONS_SCORE: 1.0617

RIG_SCORE: 0.7688

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N38S	TCGA-E6-A2P9	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	0.1389
p.N38S	TCGA-EO-A22X	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	0.1389
p.N38S	DO43907	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	0.1389
p.N38S	DO43714	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	0.1389
p.S47F	TCGA-W3-AA1V	SKCM	TCGA	VVSTS	DEG_SPOP_SBC_1	0.9093
p.S47F	DO51276	SKCM	ICGC	VVSTS	DEG_SPOP_SBC_1	0.9093
p.D42N	SIDM00660	Colorectal Carcinoma	GDSC	VVSTS	DEG_SPOP_SBC_1	0.25
p.D42N	ACH-000985	Colon/Colorectal Cancer	CCLE	VVSTS	DEG_SPOP_SBC_1	0.25
p.D42N	LS-411N	large_intestine	COSMIC	VVSTS	DEG_SPOP_SBC_1	0.25
p.E59K	ACH-002357	Non-Cancerous	CCLE	VVSTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_SPOP_SBC_1	231:235	VVSTS	SPOP	0.8956	More...
O95235	Kinesin-like protein KIF20A	DEG_SPOP_SBC_1	45:49	VVSTS	SPOP	0.9985	More...
O95600	Krueppel-like factor 8	DEG_SPOP_SBC_1	121:125	VVSTS	SPOP	0.8645	More...
P23469	Receptor-type tyrosine-protein phosphatase epsilon	DEG_SPOP_SBC_1	78:82	VVSTS	SPOP	0.6754	More...
P51795	H	DEG_SPOP_SBC_1	724:728	VVSTS	SPOP	0.9829	More...
Q13422	DNA-binding protein Ikaros	DEG_SPOP_SBC_1	451:455	VVSTS	SPOP	0.7186	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1171:1175	VVSTS	SPOP	0.7463	More...
Q9H7D0	Dedicator of cytokinesis protein 5	DEG_SPOP_SBC_1	1679:1683	VVSTS	SPOP	0.9974	More...
O15016	Tripartite motif-containing protein 66	DEG_SPOP_SBC_1	816:820	VVSTS	SPOP	0.6338	More...
Q96BU1	S100P-binding protein	DEG_SPOP_SBC_1	270:274	VVSTS	SPOP	0.9689	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons