DegronMD - P23469(PTPRE)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R70S	TCGA-50-5930	LUAD	TCGA	VVSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.1111
p.R70S	DO25189	LUAD	ICGC	VVSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.1111
p.R75M	TCGA-55-7907	LUAD	TCGA	VVSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.25
p.R75M	DO25396	LUAD	ICGC	VVSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.25
p.S174F	TCGA-AB-2833	LAML	TCGA	SRVILSQLD	DEG_APCC_DBOX_1	174:182	Mutation altering degron motif	0.7982
p.S174F	DO21679	LAML	ICGC	SRVILSQLD	DEG_APCC_DBOX_1	174:182	Mutation altering degron motif	0.7982
p.S80N	TCGA-CK-4951	COAD	TCGA	VVSTS	DEG_SPOP_SBC_1	78:82	Mutation altering degron motif	0.818
p.S80N	DO10582	COAD	ICGC	VVSTS	DEG_SPOP_SBC_1	78:82	Mutation altering degron motif	0.818
p.H173N	TCGA-D3-A1Q1	SKCM	TCGA	SRVILSQLD	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.3056
p.H173N	DO37445	SKCM	ICGC	SRVILSQLD	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.3056
p.P170T	TCGA-DD-A73C	LIHC	TCGA	SRVILSQLD	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.2222
p.P170T	DO48593	LIHC	ICGC	SRVILSQLD	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.2222
p.C186S	TCGA-EE-A29D	SKCM	TCGA	SRVILSQLD	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.2222
p.C186S	DO38123	SKCM	ICGC	SRVILSQLD	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.2222
p.R175M	TCGA-EE-A29E	SKCM	TCGA	SRVILSQLD	DEG_APCC_DBOX_1	174:182	Mutation altering degron motif	0.8632
p.R175S	TCGA-EE-A2MM	SKCM	TCGA	SRVILSQLD	DEG_APCC_DBOX_1	174:182	Mutation altering degron motif	0.7427
p.G183V	TCGA-EE-A2MM	SKCM	TCGA	SRVILSQLD	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.3056
p.G183V	DO37770	SKCM	ICGC	SRVILSQLD	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.3056
p.G89R	TCGA-EE-A2MR	SKCM	TCGA	VVSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.1389
p.G89R	DO228014	SKCA	ICGC	VVSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.1389
p.G89R	DO37819	SKCM	ICGC	VVSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.1389
p.P185S	TCGA-EY-A1GI	UCEC	TCGA	SRVILSQLD	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.25
p.P185S	DO41211	UCEC	ICGC	SRVILSQLD	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.25
p.R175G	TCGA-FR-A8YC	SKCM	TCGA	SRVILSQLD	DEG_APCC_DBOX_1	174:182	Mutation altering degron motif	0.7568
p.R175G	DO50301	SKCM	ICGC	SRVILSQLD	DEG_APCC_DBOX_1	174:182	Mutation altering degron motif	0.7568
p.V78A	DO228664	LICA	ICGC	VVSTS	DEG_SPOP_SBC_1	78:82	Mutation altering degron motif	0.5825
p.D182Y	DO228948	LICA	ICGC	SRVILSQLD	DEG_APCC_DBOX_1	174:182	Mutation altering degron motif	0.6214
p.S80I	DO229008	LICA	ICGC	VVSTS	DEG_SPOP_SBC_1	78:82	Mutation altering degron motif	0.8453
p.Q74L	DO27843	MALY	ICGC	VVSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.2222
p.P166S	DO50725	ORCA	ICGC	SRVILSQLD	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.1111
p.D83N	SIDM00534	Colorectal Carcinoma	GDSC	VVSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.3056
p.D83N	ACH-000986	Colon/Colorectal Cancer	CCLE	VVSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.3056
p.D83N	HT-115	large intestine	COSMIC	VVSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.3056
p.L169I	ACH-001610	Brain Cancer	CCLE	SRVILSQLD	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.1944
p.R69K	SW684	soft tissue	COSMIC	VVSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.0833

Kaplan plot for PTPRE in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTPRE

UniProt ID: P23469

Entrez ID: 5791

Protein name: Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PTPRE in