DegronMD

Uniprot ID: P23469

Source protein: Receptor-type tyrosine-protein phosphatase epsilon

Source gene: PTPRE

Class: DEG_APCC_DBOX_1

Location: 174:182

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6724

ASA_SCORE: 48.5889

COIL: 0.4591

CONS_SCORE: 0.7444

DSS_SCORE: 0.2876

HELIX: 0.0208

FCONS_SCORE: 0.9227

RIG_SCORE: 0.8063

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S174F	TCGA-AB-2833	LAML	TCGA	SRVILSQLD	DEG_APCC_DBOX_1	0.7982
p.S174F	DO21679	LAML	ICGC	SRVILSQLD	DEG_APCC_DBOX_1	0.7982
p.H173N	TCGA-D3-A1Q1	SKCM	TCGA	SRVILSQLD	DEG_APCC_DBOX_1	0.3056
p.H173N	DO37445	SKCM	ICGC	SRVILSQLD	DEG_APCC_DBOX_1	0.3056
p.P170T	TCGA-DD-A73C	LIHC	TCGA	SRVILSQLD	DEG_APCC_DBOX_1	0.2222
p.P170T	DO48593	LIHC	ICGC	SRVILSQLD	DEG_APCC_DBOX_1	0.2222
p.C186S	TCGA-EE-A29D	SKCM	TCGA	SRVILSQLD	DEG_APCC_DBOX_1	0.2222
p.C186S	DO38123	SKCM	ICGC	SRVILSQLD	DEG_APCC_DBOX_1	0.2222
p.R175M	TCGA-EE-A29E	SKCM	TCGA	SRVILSQLD	DEG_APCC_DBOX_1	0.8632
p.R175S	TCGA-EE-A2MM	SKCM	TCGA	SRVILSQLD	DEG_APCC_DBOX_1	0.7427
p.G183V	TCGA-EE-A2MM	SKCM	TCGA	SRVILSQLD	DEG_APCC_DBOX_1	0.3056
p.G183V	DO37770	SKCM	ICGC	SRVILSQLD	DEG_APCC_DBOX_1	0.3056
p.P185S	TCGA-EY-A1GI	UCEC	TCGA	SRVILSQLD	DEG_APCC_DBOX_1	0.25
p.P185S	DO41211	UCEC	ICGC	SRVILSQLD	DEG_APCC_DBOX_1	0.25
p.R175G	TCGA-FR-A8YC	SKCM	TCGA	SRVILSQLD	DEG_APCC_DBOX_1	0.7568
p.R175G	DO50301	SKCM	ICGC	SRVILSQLD	DEG_APCC_DBOX_1	0.7568
p.D182Y	DO228948	LICA	ICGC	SRVILSQLD	DEG_APCC_DBOX_1	0.6214
p.P166S	DO50725	ORCA	ICGC	SRVILSQLD	DEG_APCC_DBOX_1	0.1111
p.L169I	ACH-001610	Brain Cancer	CCLE	SRVILSQLD	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23469	Receptor-type tyrosine-protein phosphatase epsilon	DEG_APCC_DBOX_1	174:182	SRVILSQLD	APC,CDC20,FZR1	0.6724	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons