DegronMD - O95235(KIF20A)

FUNCTION: Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}.

GO - Biological processes (BP): microtubule-based movement [GO:0007018]; microtubule bundle formation [GO:0001578]; midbody abscission [GO:0061952]; mitotic cytokinesis [GO:0000281]; protein transport [GO:0015031]; regulation of cytokinesis [GO:0032465]

GO - Molecular function (MF): ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; protein kinase binding [GO:0019901]

GO - Cellular component (CC): Golgi apparatus [GO:0005794]; intercellular bridge [GO:0045171]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
LRTELQKLG	DEG_APCC_DBOX_1	APC,CDC20,FZR1	Kinesin-like protein KIF20A	744:752	More..
VVSTS	DEG_SPOP_SBC_1	SPOP	Kinesin-like protein KIF20A	45:49	More..
LVPFRD	LIG_APCC_ABBA_1	APC,CDC20,FZR1	Kinesin-like protein KIF20A	456:461	More..
KRSVYIE	LIG_APCC_ABBAyCdc20_2	APC,CDC20,FZR1	Kinesin-like protein KIF20A	242:248	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S47F	TCGA-W3-AA1V	SKCM	TCGA	VVSTS	DEG_SPOP_SBC_1	45:49	Mutation altering degron motif	0.9093
p.S47F	DO51276	SKCM	ICGC	VVSTS	DEG_SPOP_SBC_1	45:49	Mutation altering degron motif	0.9093
p.R745W	TCGA-CZ-5465	KIRC	TCGA	LRTELQKLG	DEG_APCC_DBOX_1	744:752	Mutation altering degron motif	0.8634
p.R754C	DO20525	KIRC	ICGC	LRTELQKLG	DEG_APCC_DBOX_1	744:752	Mutation blocking phosphorylation signal	0.7222
p.R754C	HCC2998	large intestine	COSMIC	LRTELQKLG	DEG_APCC_DBOX_1	744:752	Mutation blocking phosphorylation signal	0.7222
p.G458D	D-502MG	central nervous system	COSMIC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.7198
p.R460C	SIDM00429	B-Lymphoblastic Leukemia	GDSC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.719
p.R460C	ACH-000938	Leukemia	CCLE	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.719
p.R460C	NALM-6	haematopoietic and lymphoid tissue	COSMIC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.719
p.R460H	TCGA-A5-A0G2	UCEC	TCGA	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.7133
p.R460H	DO229061	LICA	ICGC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.7133
p.R460H	DO41235	UCEC	ICGC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.7133
p.R460H	SIDM00214	Colorectal Carcinoma	GDSC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.7133
p.R460H	ACH-000955	Colon/Colorectal Cancer	CCLE	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.7133
p.R460H	SNU-407	large intestine	COSMIC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.7133
p.T748I	NCI-H630	large intestine	COSMIC	LRTELQKLG	DEG_APCC_DBOX_1	744:752	Mutation altering degron motif	0.7078
p.F453V	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation blocking ubiquitination signal	0.6944
p.K242N	TCGA-E7-A7XN	BLCA	TCGA	KRSVYIE	LIG_APCC_ABBAyCdc20_2	242:248	Mutation altering degron motif	0.6918
p.P458S	TCGA-EE-A2MR	SKCM	TCGA	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.6752
p.P458S	DO37819	SKCM	ICGC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.6752

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIF20A

UniProt ID: O95235

Entrez ID: 10112

Protein name: Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIF20A in