DegronMD - O95235(KIF20A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R460P	TCGA-06-1801	GBM	TCGA	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.6401
p.R460P	DO11986	GBM	ICGC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.6401
p.E759Q	TCGA-18-4083	LUSC	TCGA	LRTELQKLG	DEG_APCC_DBOX_1	744:752	Mutation rewiring degron network	0.1389
p.E759Q	DO26504	LUSC	ICGC	LRTELQKLG	DEG_APCC_DBOX_1	744:752	Mutation rewiring degron network	0.1389
p.Q738K	TCGA-19-5956	GBM	TCGA	LRTELQKLG	DEG_APCC_DBOX_1	744:752	Mutation rewiring degron network	0.1667
p.E759D	TCGA-A2-A0EQ	BRCA	TCGA	LRTELQKLG	DEG_APCC_DBOX_1	744:752	Mutation rewiring degron network	0.1389
p.R460H	TCGA-A5-A0G2	UCEC	TCGA	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.7133
p.R460H	DO229061	LICA	ICGC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.7133
p.R460H	DO41235	UCEC	ICGC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.7133
p.R460H	SIDM00214	Colorectal Carcinoma	GDSC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.7133
p.R460H	ACH-000955	Colon/Colorectal Cancer	CCLE	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.7133
p.R460H	SNU-407	large intestine	COSMIC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.7133
p.R745W	TCGA-CZ-5465	KIRC	TCGA	LRTELQKLG	DEG_APCC_DBOX_1	744:752	Mutation altering degron motif	0.8634
p.N38S	TCGA-E6-A2P9	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.1389
p.N38S	TCGA-EO-A22X	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.1389
p.N38S	DO43907	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.1389
p.N38S	DO43714	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.1389
p.K242N	TCGA-E7-A7XN	BLCA	TCGA	KRSVYIE	LIG_APCC_ABBAyCdc20_2	242:248	Mutation altering degron motif	0.6918
p.P458S	TCGA-EE-A2MR	SKCM	TCGA	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.6752
p.P458S	DO37819	SKCM	ICGC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.6752
p.R250Q	TCGA-SP-A6QD	PCPG	TCGA	KRSVYIE	LIG_APCC_ABBAyCdc20_2	242:248	Mutation rewiring degron network	0.2778
p.R451W	TCGA-VQ-AA6G	STAD	TCGA	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation rewiring degron network	0.1944
p.R451W	DO51801	STAD	ICGC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation rewiring degron network	0.1944
p.S47F	TCGA-W3-AA1V	SKCM	TCGA	VVSTS	DEG_SPOP_SBC_1	45:49	Mutation altering degron motif	0.9093
p.S47F	DO51276	SKCM	ICGC	VVSTS	DEG_SPOP_SBC_1	45:49	Mutation altering degron motif	0.9093
p.E747K	TCGA-YC-A89H	BLCA	TCGA	LRTELQKLG	DEG_APCC_DBOX_1	744:752	Mutation altering degron motif	0.591
p.E741D	DO4773	BRCA	ICGC	LRTELQKLG	DEG_APCC_DBOX_1	744:752	Mutation rewiring degron network	0.25
p.R466Q	DO234375	ESAD	ICGC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation rewiring degron network	0.1944
p.N465H	DO233867	GACA	ICGC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation rewiring degron network	0.2222
p.R754C	DO20525	KIRC	ICGC	LRTELQKLG	DEG_APCC_DBOX_1	744:752	Mutation blocking phosphorylation signal	0.7222
p.R754C	HCC2998	large intestine	COSMIC	LRTELQKLG	DEG_APCC_DBOX_1	744:752	Mutation blocking phosphorylation signal	0.7222
p.A758S	DO229034	LICA	ICGC	LRTELQKLG	DEG_APCC_DBOX_1	744:752	Mutation rewiring degron network	0.1667
p.S462I	DO229035	LICA	ICGC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation rewiring degron network	0.3056
p.S250N	DO229268	THCA	ICGC	KRSVYIE	LIG_APCC_ABBAyCdc20_2	242:248	Mutation rewiring degron network	0.2778
p.F471V	SIDM00422	Hodgkin's Lymphoma	GDSC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation rewiring degron network	0.0556
p.F471V	ACH-001203	Lymphoma	CCLE	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation rewiring degron network	0.0556
p.F471V	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation rewiring degron network	0.0556
p.D42N	SIDM00660	Colorectal Carcinoma	GDSC	VVSTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.25
p.D42N	ACH-000985	Colon/Colorectal Cancer	CCLE	VVSTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.25
p.D42N	LS-411N	large intestine	COSMIC	VVSTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.25
p.R460C	SIDM00429	B-Lymphoblastic Leukemia	GDSC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.719
p.R460C	ACH-000938	Leukemia	CCLE	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.719
p.R460C	NALM-6	haematopoietic and lymphoid tissue	COSMIC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.719
p.Q446R	SIDM00576	Acute Myeloid Leukemia	GDSC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation rewiring degron network	0.0556
p.Q446R	ACH-002290	Leukemia	CCLE	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation rewiring degron network	0.0556
p.Q446R	NKM-1	haematopoietic and lymphoid tissue	COSMIC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation rewiring degron network	0.0556
p.V245I	SIDM01608	Endometrial Carcinoma	GDSC	KRSVYIE	LIG_APCC_ABBAyCdc20_2	242:248	Mutation altering degron motif	0.5965
p.V245I	ACH-000990	Endometrial/Uterine Cancer	CCLE	KRSVYIE	LIG_APCC_ABBAyCdc20_2	242:248	Mutation altering degron motif	0.5965
p.E59K	ACH-002357	Non-Cancerous	CCLE	VVSTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.0556
p.P468L	BC-3	haematopoietic and lymphoid tissue	COSMIC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation rewiring degron network	0.1389
p.T253A	SNU-1040	large intestine	COSMIC	KRSVYIE	LIG_APCC_ABBAyCdc20_2	242:248	Mutation rewiring degron network	0.1944
p.S460P	LB373-MEL-D	skin	COSMIC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.6752
p.G458D	D-502MG	central nervous system	COSMIC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.7198
p.T748I	NCI-H630	large intestine	COSMIC	LRTELQKLG	DEG_APCC_DBOX_1	744:752	Mutation altering degron motif	0.7078
p.A756G	YKG-1	central nervous system	COSMIC	LRTELQKLG	DEG_APCC_DBOX_1	744:752	Mutation rewiring degron network	0.2222
p.F453V	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	LVPFRD	LIG_APCC_ABBA_1	456:461	Mutation blocking ubiquitination signal	0.6944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIF20A

UniProt ID: O95235

Entrez ID: 10112

Protein name: Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIF20A in