DegronMD

Uniprot ID: O95235

Source protein: Kinesin-like protein KIF20A

Source gene: KIF20A

Class: DEG_APCC_DBOX_1

Location: 744:752

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6881

ASA_SCORE: 81.1778

COIL: 0.0208

CONS_SCORE: 0.4778

DSS_SCORE: 0.351

HELIX: 0.9792

FCONS_SCORE: 1.0826

RIG_SCORE: 0.8161

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E759Q	TCGA-18-4083	LUSC	TCGA	LRTELQKLG	DEG_APCC_DBOX_1	0.1389
p.E759Q	DO26504	LUSC	ICGC	LRTELQKLG	DEG_APCC_DBOX_1	0.1389
p.Q738K	TCGA-19-5956	GBM	TCGA	LRTELQKLG	DEG_APCC_DBOX_1	0.1667
p.E759D	TCGA-A2-A0EQ	BRCA	TCGA	LRTELQKLG	DEG_APCC_DBOX_1	0.1389
p.R745W	TCGA-CZ-5465	KIRC	TCGA	LRTELQKLG	DEG_APCC_DBOX_1	0.8634
p.E747K	TCGA-YC-A89H	BLCA	TCGA	LRTELQKLG	DEG_APCC_DBOX_1	0.591
p.E741D	DO4773	BRCA	ICGC	LRTELQKLG	DEG_APCC_DBOX_1	0.25
p.R754C	DO20525	KIRC	ICGC	LRTELQKLG	DEG_APCC_DBOX_1	0.7222
p.R754C	HCC2998	large_intestine	COSMIC	LRTELQKLG	DEG_APCC_DBOX_1	0.7222
p.A758S	DO229034	LICA	ICGC	LRTELQKLG	DEG_APCC_DBOX_1	0.1667
p.T748I	NCI-H630	large_intestine	COSMIC	LRTELQKLG	DEG_APCC_DBOX_1	0.7078
p.A756G	YKG-1	central_nervous_system	COSMIC	LRTELQKLG	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95235	Kinesin-like protein KIF20A	DEG_APCC_DBOX_1	744:752	LRTELQKLG	APC,CDC20,FZR1	0.6881	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons