DegronMD

Uniprot ID: O95235

Source protein: Kinesin-like protein KIF20A

Source gene: KIF20A

Class: LIG_APCC_ABBAyCdc20_2

Location: 242:248

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6519

ASA_SCORE: 82.1

COIL: 0.4316

CONS_SCORE: 0.225

DSS_SCORE: 0.2731

HELIX: 0.1521

FCONS_SCORE: 0.78

RIG_SCORE: 0.8216

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K242N	TCGA-E7-A7XN	BLCA	TCGA	KRSVYIE	LIG_APCC_ABBAyCdc20_2	0.6918
p.R250Q	TCGA-SP-A6QD	PCPG	TCGA	KRSVYIE	LIG_APCC_ABBAyCdc20_2	0.2778
p.S250N	DO229268	THCA	ICGC	KRSVYIE	LIG_APCC_ABBAyCdc20_2	0.2778
p.V245I	SIDM01608	Endometrial Carcinoma	GDSC	KRSVYIE	LIG_APCC_ABBAyCdc20_2	0.5965
p.V245I	ACH-000990	Endometrial/Uterine Cancer	CCLE	KRSVYIE	LIG_APCC_ABBAyCdc20_2	0.5965
p.T253A	SNU-1040	large_intestine	COSMIC	KRSVYIE	LIG_APCC_ABBAyCdc20_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95235	Kinesin-like protein KIF20A	LIG_APCC_ABBAyCdc20_2	242:248	KRSVYIE	APC,CDC20,FZR1	0.6519	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons