DegronMD

Uniprot ID: O95235

Source protein: Kinesin-like protein KIF20A

Source gene: KIF20A

Class: LIG_APCC_ABBA_1

Location: 456:461

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9122

ASA_SCORE: 55.3667

COIL: 0.8128

CONS_SCORE: 0.75

DSS_SCORE: 0.3957

HELIX: 0.1075

FCONS_SCORE: 1.1227

RIG_SCORE: 0.8252

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R460P	TCGA-06-1801	GBM	TCGA	LVPFRD	LIG_APCC_ABBA_1	0.6401
p.R460P	DO11986	GBM	ICGC	LVPFRD	LIG_APCC_ABBA_1	0.6401
p.R460H	TCGA-A5-A0G2	UCEC	TCGA	LVPFRD	LIG_APCC_ABBA_1	0.7133
p.R460H	DO229061	LICA	ICGC	LVPFRD	LIG_APCC_ABBA_1	0.7133
p.R460H	DO41235	UCEC	ICGC	LVPFRD	LIG_APCC_ABBA_1	0.7133
p.R460H	SIDM00214	Colorectal Carcinoma	GDSC	LVPFRD	LIG_APCC_ABBA_1	0.7133
p.R460H	ACH-000955	Colon/Colorectal Cancer	CCLE	LVPFRD	LIG_APCC_ABBA_1	0.7133
p.R460H	SNU-407	large_intestine	COSMIC	LVPFRD	LIG_APCC_ABBA_1	0.7133
p.P458S	TCGA-EE-A2MR	SKCM	TCGA	LVPFRD	LIG_APCC_ABBA_1	0.6752
p.P458S	DO37819	SKCM	ICGC	LVPFRD	LIG_APCC_ABBA_1	0.6752
p.R451W	TCGA-VQ-AA6G	STAD	TCGA	LVPFRD	LIG_APCC_ABBA_1	0.1944
p.R451W	DO51801	STAD	ICGC	LVPFRD	LIG_APCC_ABBA_1	0.1944
p.R466Q	DO234375	ESAD	ICGC	LVPFRD	LIG_APCC_ABBA_1	0.1944
p.N465H	DO233867	GACA	ICGC	LVPFRD	LIG_APCC_ABBA_1	0.2222
p.S462I	DO229035	LICA	ICGC	LVPFRD	LIG_APCC_ABBA_1	0.3056
p.F471V	SIDM00422	Hodgkin's Lymphoma	GDSC	LVPFRD	LIG_APCC_ABBA_1	0.0556
p.F471V	ACH-001203	Lymphoma	CCLE	LVPFRD	LIG_APCC_ABBA_1	0.0556
p.F471V	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	LVPFRD	LIG_APCC_ABBA_1	0.0556
p.R460C	SIDM00429	B-Lymphoblastic Leukemia	GDSC	LVPFRD	LIG_APCC_ABBA_1	0.719
p.R460C	ACH-000938	Leukemia	CCLE	LVPFRD	LIG_APCC_ABBA_1	0.719
p.R460C	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	LVPFRD	LIG_APCC_ABBA_1	0.719
p.Q446R	SIDM00576	Acute Myeloid Leukemia	GDSC	LVPFRD	LIG_APCC_ABBA_1	0.0556
p.Q446R	ACH-002290	Leukemia	CCLE	LVPFRD	LIG_APCC_ABBA_1	0.0556
p.Q446R	NKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	LVPFRD	LIG_APCC_ABBA_1	0.0556
p.P468L	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	LVPFRD	LIG_APCC_ABBA_1	0.1389
p.S460P	LB373-MEL-D	skin	COSMIC	LVPFRD	LIG_APCC_ABBA_1	0.6752
p.G458D	D-502MG	central_nervous_system	COSMIC	LVPFRD	LIG_APCC_ABBA_1	0.7198
p.F453V	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	LVPFRD	LIG_APCC_ABBA_1	0.6944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LVPFRD

Degron related mutations and impact score

Drug responses associated with KIF20A mutations

All proteins holding degron of LVPFRD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95235	Kinesin-like protein KIF20A	LIG_APCC_ABBA_1	456:461	LVPFRD	APC,CDC20,FZR1	0.9122	More...