DegronMD

Uniprot ID: Q13422

Source protein: DNA-binding protein Ikaros

Source gene: IKZF1

Class: DEG_SPOP_SBC_1

Location: 451:455

E3 ligase: SPOP

DEGRON score: 0.7186

ASA_SCORE: 65.92

COIL: 0.607

CONS_SCORE: 0.5293

DSS_SCORE: 0.2709

HELIX: 0.0098

FCONS_SCORE: 0.9628

RIG_SCORE: 0.7576

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q458H	TCGA-44-7662	LUAD	TCGA	VVSTS	DEG_SPOP_SBC_1	0.25
p.Q458H	DO23597	LUAD	ICGC	VVSTS	DEG_SPOP_SBC_1	0.25
p.Q458H	ACH-001719	Ovarian Cancer	CCLE	VVSTS	DEG_SPOP_SBC_1	0.25
p.D459Y	TCGA-44-7662	LUAD	TCGA	VVSTS	DEG_SPOP_SBC_1	0.2222
p.D459Y	DO23597	LUAD	ICGC	VVSTS	DEG_SPOP_SBC_1	0.2222
p.E462Q	TCGA-70-6722	LUSC	TCGA	VVSTS	DEG_SPOP_SBC_1	0.1389
p.E462Q	DO27755	LUSC	ICGC	VVSTS	DEG_SPOP_SBC_1	0.1389
p.R445L	TCGA-86-8073	LUAD	TCGA	VVSTS	DEG_SPOP_SBC_1	0.6111
p.R445L	DO229015	LICA	ICGC	VVSTS	DEG_SPOP_SBC_1	0.6111
p.R445L	DO23624	LUAD	ICGC	VVSTS	DEG_SPOP_SBC_1	0.6111
p.S457N	TCGA-AA-3492	COAD	TCGA	VVSTS	DEG_SPOP_SBC_1	0.2778
p.S457N	DO8224	COAD	ICGC	VVSTS	DEG_SPOP_SBC_1	0.2778
p.G443D	TCGA-AA-3672	COAD	TCGA	VVSTS	DEG_SPOP_SBC_1	0.1111
p.G443D	TCGA-AX-A1CE	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	0.1111
p.G443D	DO9010	COAD	ICGC	VVSTS	DEG_SPOP_SBC_1	0.1111
p.G443D	DO42280	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	0.1111
p.S457R	TCGA-D3-A5GR	SKCM	TCGA	VVSTS	DEG_SPOP_SBC_1	0.2778
p.S457R	DO47436	SKCM	ICGC	VVSTS	DEG_SPOP_SBC_1	0.2778
p.G443S	TCGA-F4-6703	COAD	TCGA	VVSTS	DEG_SPOP_SBC_1	0.1111
p.G443S	DO9908	COAD	ICGC	VVSTS	DEG_SPOP_SBC_1	0.1111
p.S464L	TCGA-FI-A2D5	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	0.0833
p.S464L	DO222439	BTCA	ICGC	VVSTS	DEG_SPOP_SBC_1	0.0833
p.S464L	DO41331	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	0.0833
p.Q458K	TCGA-FS-A1ZR	SKCM	TCGA	VVSTS	DEG_SPOP_SBC_1	0.25
p.Q458K	DO37651	SKCM	ICGC	VVSTS	DEG_SPOP_SBC_1	0.25
p.E449Q	TCGA-GU-A42P	BLCA	TCGA	VVSTS	DEG_SPOP_SBC_1	0.2778
p.E449Q	DO534	BLCA	ICGC	VVSTS	DEG_SPOP_SBC_1	0.2778
p.G443V	TCGA-IB-7651	PAAD	TCGA	VVSTS	DEG_SPOP_SBC_1	0.1111
p.G443V	DO46657	PAAD	ICGC	VVSTS	DEG_SPOP_SBC_1	0.1111
p.R445H	TCGA-RS-A6TO	HNSC	TCGA	VVSTS	DEG_SPOP_SBC_1	0.6111
p.R445H	DO219060	HNSC	ICGC	VVSTS	DEG_SPOP_SBC_1	0.6111
p.R460W	DO221161	AML	ICGC	VVSTS	DEG_SPOP_SBC_1	0.6389
p.F463L	DO222762	COCA	ICGC	VVSTS	DEG_SPOP_SBC_1	0.2222
p.R460L	DO229032	LICA	ICGC	VVSTS	DEG_SPOP_SBC_1	0.6389
p.D446Y	DO229009	LICA	ICGC	VVSTS	DEG_SPOP_SBC_1	0.1944
p.E465K	SIDM00524	Small Cell Lung Carcinoma	GDSC	VVSTS	DEG_SPOP_SBC_1	0.0556
p.E465K	ACH-000703	Lung Cancer	CCLE	VVSTS	DEG_SPOP_SBC_1	0.0556
p.E465K	DMS-79	lung	COSMIC	VVSTS	DEG_SPOP_SBC_1	0.0556
p.S445P	SIDM01176	B-Lymphoblastic Leukemia	GDSC	VVSTS	DEG_SPOP_SBC_1	0.6111
p.E443D	SIDM00077	Oral Cavity Carcinoma	GDSC	VVSTS	DEG_SPOP_SBC_1	0.1111
p.E443D	ACH-001331	Head and Neck Cancer	CCLE	VVSTS	DEG_SPOP_SBC_1	0.1111
p.E443D	BICR10	upper_aerodigestive_tract	COSMIC	VVSTS	DEG_SPOP_SBC_1	0.1111
p.A448V	ACH-001719	Ovarian Cancer	CCLE	VVSTS	DEG_SPOP_SBC_1	0.25
p.S457T	CAPAN-1	pancreas	COSMIC	VVSTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_SPOP_SBC_1	231:235	VVSTS	SPOP	0.8956	More...
O95235	Kinesin-like protein KIF20A	DEG_SPOP_SBC_1	45:49	VVSTS	SPOP	0.9985	More...
O95600	Krueppel-like factor 8	DEG_SPOP_SBC_1	121:125	VVSTS	SPOP	0.8645	More...
P23469	Receptor-type tyrosine-protein phosphatase epsilon	DEG_SPOP_SBC_1	78:82	VVSTS	SPOP	0.6754	More...
P51795	H	DEG_SPOP_SBC_1	724:728	VVSTS	SPOP	0.9829	More...
Q13422	DNA-binding protein Ikaros	DEG_SPOP_SBC_1	451:455	VVSTS	SPOP	0.7186	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1171:1175	VVSTS	SPOP	0.7463	More...
Q9H7D0	Dedicator of cytokinesis protein 5	DEG_SPOP_SBC_1	1679:1683	VVSTS	SPOP	0.9974	More...
O15016	Tripartite motif-containing protein 66	DEG_SPOP_SBC_1	816:820	VVSTS	SPOP	0.6338	More...
Q96BU1	S100P-binding protein	DEG_SPOP_SBC_1	270:274	VVSTS	SPOP	0.9689	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VVSTS

Degron related mutations and impact score

Drug responses associated with IKZF1 mutations

All proteins holding degron of VVSTS