DegronMD - Q9H7D0(DOCK5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1791S	TCGA-12-0829	GBM	TCGA	PPLTPKAT	DEG_SCF_FBW7_1	1791:1798	Mutation altering degron motif	0.6752
p.P1791S	DO11166	GBM	ICGC	PPLTPKAT	DEG_SCF_FBW7_1	1791:1798	Mutation altering degron motif	0.6752
p.P1438L	TCGA-A6-5660	COAD	TCGA	PPSY	ITCH	1438:1441	Mutation altering degron motif	0.7582
p.P1438L	DO7972	COAD	ICGC	PPSY	ITCH	1438:1441	Mutation altering degron motif	0.7582
p.R1669S	TCGA-AO-A0J5	BRCA	TCGA	VVSTS	DEG_SPOP_SBC_1	1679:1683	Mutation rewiring degron network	0.0556
p.R1669S	DO1429	BRCA	ICGC	VVSTS	DEG_SPOP_SBC_1	1679:1683	Mutation rewiring degron network	0.0556
p.E1448D	TCGA-B5-A11E	UCEC	TCGA	PPSY	ITCH	1438:1441	Mutation rewiring degron network	0.1389
p.E1448D	DO41644	UCEC	ICGC	PPSY	ITCH	1438:1441	Mutation rewiring degron network	0.1389
p.P1795H	TCGA-B5-A3FC	UCEC	TCGA	PPLTPKAT	DEG_SCF_FBW7_1	1791:1798	Mutation altering degron motif	0.7694
p.P1795H	DO41871	UCEC	ICGC	PPLTPKAT	DEG_SCF_FBW7_1	1791:1798	Mutation altering degron motif	0.7694
p.A1797V	TCGA-BH-A0EE	BRCA	TCGA	PPLTPKAT	DEG_SCF_FBW7_1	1791:1798	Mutation altering degron motif	0.5825
p.A1797V	DO6088	BRCA	ICGC	PPLTPKAT	DEG_SCF_FBW7_1	1791:1798	Mutation altering degron motif	0.5825
p.P1804L	TCGA-BR-8078	STAD	TCGA	PPLTPKAT	DEG_SCF_FBW7_1	1791:1798	Mutation rewiring degron network	0.1667
p.P1804L	DO38288	STAD	ICGC	PPLTPKAT	DEG_SCF_FBW7_1	1791:1798	Mutation rewiring degron network	0.1667
p.S1781L	TCGA-BR-8285	STAD	TCGA	PPLTPKAT	DEG_SCF_FBW7_1	1791:1798	Mutation blocking phosphorylation signal	0.5
p.S1781L	DO38479	STAD	ICGC	PPLTPKAT	DEG_SCF_FBW7_1	1791:1798	Mutation blocking phosphorylation signal	0.5
p.S1803P	TCGA-EO-A22T	UCEC	TCGA	PPLTPKAT	DEG_SCF_FBW7_1	1791:1798	Mutation blocking phosphorylation signal	0.6389
p.S1803P	DO42320	UCEC	ICGC	PPLTPKAT	DEG_SCF_FBW7_1	1791:1798	Mutation blocking phosphorylation signal	0.6389
p.T1682I	TCGA-PK-A5HB	ACC	TCGA	VVSTS	DEG_SPOP_SBC_1	1679:1683	Mutation altering degron motif	0.7078
p.T1682S	DO233271	GACA	ICGC	VVSTS	DEG_SPOP_SBC_1	1679:1683	Mutation altering degron motif	0.6005
p.R1799S	DO229034	LICA	ICGC	PPLTPKAT	DEG_SCF_FBW7_1	1791:1798	Mutation rewiring degron network	0.3056
p.P1447A	DO35118	PACA	ICGC	PPSY	ITCH	1438:1441	Mutation rewiring degron network	0.1667
p.V1446F	DO51493	PACA	ICGC	PPSY	ITCH	1438:1441	Mutation rewiring degron network	0.1944
p.D1443N	DO229272	THCA	ICGC	PPSY	ITCH	1438:1441	Mutation rewiring degron network	0.2778
p.S1805L	SIDM01175	Other Sarcomas	GDSC	PPLTPKAT	DEG_SCF_FBW7_1	1791:1798	Mutation blocking phosphorylation signal	0.5833
p.S1805L	ACH-002309	Sarcoma	CCLE	PPLTPKAT	DEG_SCF_FBW7_1	1791:1798	Mutation blocking phosphorylation signal	0.5833
p.S1805L	SW684	soft tissue	COSMIC	PPLTPKAT	DEG_SCF_FBW7_1	1791:1798	Mutation blocking phosphorylation signal	0.5833
p.S1803F	SIDM01696	Mesothelioma	GDSC	PPLTPKAT	DEG_SCF_FBW7_1	1791:1798	Mutation blocking phosphorylation signal	0.6389
p.S1803F	ACH-000645	Lung Cancer	CCLE	PPLTPKAT	DEG_SCF_FBW7_1	1791:1798	Mutation blocking phosphorylation signal	0.6389
p.L1801I	ACH-000499	Bone Cancer	CCLE	PPLTPKAT	DEG_SCF_FBW7_1	1791:1798	Mutation rewiring degron network	0.25

Kaplan plot for DOCK5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DOCK5

UniProt ID: Q9H7D0

Entrez ID: 80005

Protein name: Dedicator of cytokinesis protein 5

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DOCK5 in