DegronMD

Uniprot ID: Q9H7D0

Source protein: Dedicator of cytokinesis protein 5

Source gene: DOCK5

Class: DEG_SCF_FBW7_1

Location: 1791:1798

E3 ligase: FBXW7

DEGRON score: 0.9948

ASA_SCORE: 91.525

COIL: 0.952

CONS_SCORE: 0.2373

DSS_SCORE: 0.7905

HELIX: 0.03

FCONS_SCORE: 1.0304

RIG_SCORE: 0.5989

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1791S	TCGA-12-0829	GBM	TCGA	PPLTPKAT	DEG_SCF_FBW7_1	0.6752
p.P1791S	DO11166	GBM	ICGC	PPLTPKAT	DEG_SCF_FBW7_1	0.6752
p.P1795H	TCGA-B5-A3FC	UCEC	TCGA	PPLTPKAT	DEG_SCF_FBW7_1	0.7694
p.P1795H	DO41871	UCEC	ICGC	PPLTPKAT	DEG_SCF_FBW7_1	0.7694
p.A1797V	TCGA-BH-A0EE	BRCA	TCGA	PPLTPKAT	DEG_SCF_FBW7_1	0.5825
p.A1797V	DO6088	BRCA	ICGC	PPLTPKAT	DEG_SCF_FBW7_1	0.5825
p.P1804L	TCGA-BR-8078	STAD	TCGA	PPLTPKAT	DEG_SCF_FBW7_1	0.1667
p.P1804L	DO38288	STAD	ICGC	PPLTPKAT	DEG_SCF_FBW7_1	0.1667
p.S1781L	TCGA-BR-8285	STAD	TCGA	PPLTPKAT	DEG_SCF_FBW7_1	0.5
p.S1781L	DO38479	STAD	ICGC	PPLTPKAT	DEG_SCF_FBW7_1	0.5
p.S1803P	TCGA-EO-A22T	UCEC	TCGA	PPLTPKAT	DEG_SCF_FBW7_1	0.6389
p.S1803P	DO42320	UCEC	ICGC	PPLTPKAT	DEG_SCF_FBW7_1	0.6389
p.R1799S	DO229034	LICA	ICGC	PPLTPKAT	DEG_SCF_FBW7_1	0.3056
p.S1805L	SIDM01175	Other Sarcomas	GDSC	PPLTPKAT	DEG_SCF_FBW7_1	0.5833
p.S1805L	ACH-002309	Sarcoma	CCLE	PPLTPKAT	DEG_SCF_FBW7_1	0.5833
p.S1805L	SW684	soft_tissue	COSMIC	PPLTPKAT	DEG_SCF_FBW7_1	0.5833
p.S1803F	SIDM01696	Mesothelioma	GDSC	PPLTPKAT	DEG_SCF_FBW7_1	0.6389
p.S1803F	ACH-000645	Lung Cancer	CCLE	PPLTPKAT	DEG_SCF_FBW7_1	0.6389
p.L1801I	ACH-000499	Bone Cancer	CCLE	PPLTPKAT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H7D0	Dedicator of cytokinesis protein 5	DEG_SCF_FBW7_1	1791:1798	PPLTPKAT	FBXW7	0.9948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons