DegronMD - O95600(KLF8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T124K	TCGA-06-0241	GBM	TCGA	VVSTS	DEG_SPOP_SBC_1	121:125	Mutation altering degron motif	0.7306
p.T124K	DO12460	GBM	ICGC	VVSTS	DEG_SPOP_SBC_1	121:125	Mutation altering degron motif	0.7306
p.I156F	TCGA-69-A59K	LUAD	TCGA	VLTSS	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.1111
p.I156F	DO45335	LUAD	ICGC	VLTSS	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.1111
p.A133T	TCGA-A5-A1OF	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	121:125	Mutation rewiring degron network	0.1111
p.A133T	DO42568	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	121:125	Mutation rewiring degron network	0.1111
p.Q118K	TCGA-CR-7390	HNSC	TCGA	VVSTS	DEG_SPOP_SBC_1	121:125	Mutation rewiring degron network	0.25
p.Q118K	DO14302	HNSC	ICGC	VVSTS	DEG_SPOP_SBC_1	121:125	Mutation rewiring degron network	0.25
p.K112R	TCGA-D1-A17Q	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	121:125	Mutation substituting flanking lysine	0.1944
p.K112R	DO41903	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	121:125	Mutation substituting flanking lysine	0.1944
p.T126A	TCGA-E6-A2P8	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	121:125	Mutation rewiring degron network	0.3056
p.T126A	DO40924	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	121:125	Mutation rewiring degron network	0.3056
p.L120I	TCGA-EE-A3AC	SKCM	TCGA	VVSTS	DEG_SPOP_SBC_1	121:125	Mutation rewiring degron network	0.3056
p.L120I	DO37631	SKCM	ICGC	VVSTS	DEG_SPOP_SBC_1	121:125	Mutation rewiring degron network	0.3056
p.P136H	TCGA-EO-A22R	UCEC	TCGA	VLTSS	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.1111
p.P136H	DO42713	UCEC	ICGC	VLTSS	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.1111
p.P136H	SIDM01291	Esophageal Carcinoma	GDSC	VLTSS	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.1111
p.L139M	TCGA-VR-A8EQ	ESCA	TCGA	VLTSS	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.1944
p.I135M	DO222762	COCA	ICGC	VVSTS	DEG_SPOP_SBC_1	121:125	Mutation rewiring degron network	0.0556
p.I135M	DO222762	COCA	ICGC	VLTSS	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.0833
p.M129T	DO48682	LIRI	ICGC	VVSTS	DEG_SPOP_SBC_1	121:125	Mutation rewiring degron network	0.2222
p.M129I	SIDM00973	Melanoma	GDSC	VVSTS	DEG_SPOP_SBC_1	121:125	Mutation rewiring degron network	0.2222
p.M129I	ACH-000827	Skin Cancer	CCLE	VVSTS	DEG_SPOP_SBC_1	121:125	Mutation rewiring degron network	0.2222

Kaplan plot for KLF8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KLF8

UniProt ID: O95600

Entrez ID: 11279

Protein name: Krueppel-like factor 8 (Basic krueppel-like factor 3) (Zinc finger protein 741)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KLF8 in