DegronMD

Uniprot ID: O95600

Source protein: Krueppel-like factor 8

Source gene: KLF8

Class: DEG_SPOP_SBC_1

Location: 144:148

E3 ligase: SPOP

DEGRON score: 0.9812

ASA_SCORE: 80.3

COIL: 0.8676

CONS_SCORE: 0.3441

DSS_SCORE: 0.4492

HELIX: 0.048

FCONS_SCORE: 0.9881

RIG_SCORE: 0.7102

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I156F	TCGA-69-A59K	LUAD	TCGA	VLTSS	DEG_SPOP_SBC_1	0.1111
p.I156F	DO45335	LUAD	ICGC	VLTSS	DEG_SPOP_SBC_1	0.1111
p.P136H	TCGA-EO-A22R	UCEC	TCGA	VLTSS	DEG_SPOP_SBC_1	0.1111
p.P136H	DO42713	UCEC	ICGC	VLTSS	DEG_SPOP_SBC_1	0.1111
p.P136H	SIDM01291	Esophageal Carcinoma	GDSC	VLTSS	DEG_SPOP_SBC_1	0.1111
p.L139M	TCGA-VR-A8EQ	ESCA	TCGA	VLTSS	DEG_SPOP_SBC_1	0.1944
p.I135M	DO222762	COCA	ICGC	VLTSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95600	Krueppel-like factor 8	DEG_SPOP_SBC_1	144:148	VLTSS	SPOP	0.9812	More...
Q5QGS0	Neurite extension and migration factor	DEG_SPOP_SBC_1	862:866	VLTSS	SPOP	0.9973	More...
Q5T7N3	KN motif and ankyrin repeat domain-containing protein 4	DEG_SPOP_SBC_1	486:490	VLTSS	SPOP	0.7879	More...
Q8N2C7	Protein unc-80 homolog	DEG_SPOP_SBC_1	3151:3155	VLTSS	SPOP	0.5821	More...
Q8NCF5	NFATC2-interacting protein	DEG_SPOP_SBC_1	334:338	VLTSS	SPOP	0.9389	More...
Q8TD26	Chromodomain-helicase-DNA-binding protein 6	DEG_SPOP_SBC_1	2129:2133	VLTSS	SPOP	0.9858	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4778:4782	VLTSS	SPOP	0.5936	More...
Q92879	CUGBP Elav-like family member 1	DEG_SPOP_SBC_1	293:297	VLTSS	SPOP	0.8617	More...
Q9Y5T5	Ubiquitin carboxyl-terminal hydrolase 16	DEG_SPOP_SBC_1	548:552	VLTSS	SPOP	0.9998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons