DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 4778:4782

E3 ligase: SPOP

DEGRON score: 0.5936

ASA_SCORE: 87.7

COIL: 0.8694

CONS_SCORE: 0

DSS_SCORE: 0.3441

HELIX: 0.0378

FCONS_SCORE: 0

RIG_SCORE: 0.7491

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S4781C	TCGA-AJ-A3QS	UCEC	TCGA	VLTSS	DEG_SPOP_SBC_1	0.7541
p.S4781C	DO41349	UCEC	ICGC	VLTSS	DEG_SPOP_SBC_1	0.7541
p.P4772L	TCGA-BF-A1PZ	SKCM	TCGA	VLTSS	DEG_SPOP_SBC_1	0.1667
p.P4772L	DO50279	SKCM	ICGC	VLTSS	DEG_SPOP_SBC_1	0.1667
p.V4773I	TCGA-CV-A468	HNSC	TCGA	VLTSS	DEG_SPOP_SBC_1	0.1944
p.V4773I	DO52070	HNSC	ICGC	VLTSS	DEG_SPOP_SBC_1	0.1944
p.A4787T	TCGA-D1-A16Y	UCEC	TCGA	VLTSS	DEG_SPOP_SBC_1	0.1944
p.A4787T	DO41524	UCEC	ICGC	VLTSS	DEG_SPOP_SBC_1	0.1944
p.A4787T	SIDM00433	T-Lymphoblastic Leukemia	GDSC	VLTSS	DEG_SPOP_SBC_1	0.1944
p.A4787T	ACH-000795	Leukemia	CCLE	VLTSS	DEG_SPOP_SBC_1	0.1944
p.A4787T	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	VLTSS	DEG_SPOP_SBC_1	0.1944
p.L4779V	DO224732	BRCA	ICGC	VLTSS	DEG_SPOP_SBC_1	0.5654
p.V4790G	DO44806	LICA	ICGC	VLTSS	DEG_SPOP_SBC_1	0.1111
p.S4782L	DO231593	LINC	ICGC	VLTSS	DEG_SPOP_SBC_1	0.7667
p.S4782L	ACH-001554	Eye Cancer	CCLE	VLTSS	DEG_SPOP_SBC_1	0.7667
p.S4770F	DO220902	MELA	ICGC	VLTSS	DEG_SPOP_SBC_1	0.1111
p.V4773G	DO222702	MELA	ICGC	VLTSS	DEG_SPOP_SBC_1	0.1944
p.G4788D	SIDM00120	Prostate Carcinoma	GDSC	VLTSS	DEG_SPOP_SBC_1	0.1667
p.G4788D	ACH-000979	Prostate Cancer	CCLE	VLTSS	DEG_SPOP_SBC_1	0.1667
p.G4788D	DU-145	prostate	COSMIC	VLTSS	DEG_SPOP_SBC_1	0.1667
p.G4788S	SIDM01078	Small Cell Lung Carcinoma	GDSC	VLTSS	DEG_SPOP_SBC_1	0.1667
p.G4788S	ACH-000790	Lung Cancer	CCLE	VLTSS	DEG_SPOP_SBC_1	0.1667
p.G4788S	SHP-77	lung	COSMIC	VLTSS	DEG_SPOP_SBC_1	0.1667
p.K4789N	SIDM00562	Breast Carcinoma	GDSC	VLTSS	DEG_SPOP_SBC_1	0.25
p.K4789N	ACH-002163	Breast Cancer	CCLE	VLTSS	DEG_SPOP_SBC_1	0.25
p.K4789N	MRK-nu-1	breast	COSMIC	VLTSS	DEG_SPOP_SBC_1	0.25
p.S4781F	ACH-000975	Lung Cancer	CCLE	VLTSS	DEG_SPOP_SBC_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95600	Krueppel-like factor 8	DEG_SPOP_SBC_1	144:148	VLTSS	SPOP	0.9812	More...
Q5QGS0	Neurite extension and migration factor	DEG_SPOP_SBC_1	862:866	VLTSS	SPOP	0.9973	More...
Q5T7N3	KN motif and ankyrin repeat domain-containing protein 4	DEG_SPOP_SBC_1	486:490	VLTSS	SPOP	0.7879	More...
Q8N2C7	Protein unc-80 homolog	DEG_SPOP_SBC_1	3151:3155	VLTSS	SPOP	0.5821	More...
Q8NCF5	NFATC2-interacting protein	DEG_SPOP_SBC_1	334:338	VLTSS	SPOP	0.9389	More...
Q8TD26	Chromodomain-helicase-DNA-binding protein 6	DEG_SPOP_SBC_1	2129:2133	VLTSS	SPOP	0.9858	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4778:4782	VLTSS	SPOP	0.5936	More...
Q92879	CUGBP Elav-like family member 1	DEG_SPOP_SBC_1	293:297	VLTSS	SPOP	0.8617	More...
Q9Y5T5	Ubiquitin carboxyl-terminal hydrolase 16	DEG_SPOP_SBC_1	548:552	VLTSS	SPOP	0.9998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VLTSS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of VLTSS