DegronMD

Uniprot ID: Q8N2C7

Source protein: Protein unc-80 homolog

Source gene: UNC80

Class: DEG_SPOP_SBC_1

Location: 3151:3155

E3 ligase: SPOP

DEGRON score: 0.5821

ASA_SCORE: 86.22

COIL: 0.8922

CONS_SCORE: 0.2936

DSS_SCORE: 0.584

HELIX: 0.0486

FCONS_SCORE: 1.0017

RIG_SCORE: 0.697

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E3149K	TCGA-EY-A1GI	UCEC	TCGA	VLTSS	DEG_SPOP_SBC_1	0.2778
p.S3141N	DO52699	CLLE	ICGC	VLTSS	DEG_SPOP_SBC_1	0.0556
p.V3142M	DO228491	GACA	ICGC	VLTSS	DEG_SPOP_SBC_1	0.0833
p.G3155V	DO228974	LICA	ICGC	VLTSS	DEG_SPOP_SBC_1	0.7532
p.K3145N	DO48701	LIRI	ICGC	VLTSS	DEG_SPOP_SBC_1	0.1667
p.P3151L	DO27318	LUSC	ICGC	VLTSS	DEG_SPOP_SBC_1	0.7582
p.S3141R	DO50729	ORCA	ICGC	VLTSS	DEG_SPOP_SBC_1	0.0556
p.D3160Y	DO36443	READ	ICGC	VLTSS	DEG_SPOP_SBC_1	0.1944
p.E3154D	DO42280	UCEC	ICGC	VLTSS	DEG_SPOP_SBC_1	0.6758
p.D3162Y	SIDM01126	Small Cell Lung Carcinoma	GDSC	VLTSS	DEG_SPOP_SBC_1	0.1389
p.D3162Y	NCI-H64	lung	COSMIC	VLTSS	DEG_SPOP_SBC_1	0.1389
p.E3145V	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	VLTSS	DEG_SPOP_SBC_1	0.1667
p.E3145V	ACH-001137	Lung Cancer	CCLE	VLTSS	DEG_SPOP_SBC_1	0.1667
p.E3145V	NCI-H1993	lung	COSMIC	VLTSS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95600	Krueppel-like factor 8	DEG_SPOP_SBC_1	144:148	VLTSS	SPOP	0.9812	More...
Q5QGS0	Neurite extension and migration factor	DEG_SPOP_SBC_1	862:866	VLTSS	SPOP	0.9973	More...
Q5T7N3	KN motif and ankyrin repeat domain-containing protein 4	DEG_SPOP_SBC_1	486:490	VLTSS	SPOP	0.7879	More...
Q8N2C7	Protein unc-80 homolog	DEG_SPOP_SBC_1	3151:3155	VLTSS	SPOP	0.5821	More...
Q8NCF5	NFATC2-interacting protein	DEG_SPOP_SBC_1	334:338	VLTSS	SPOP	0.9389	More...
Q8TD26	Chromodomain-helicase-DNA-binding protein 6	DEG_SPOP_SBC_1	2129:2133	VLTSS	SPOP	0.9858	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4778:4782	VLTSS	SPOP	0.5936	More...
Q92879	CUGBP Elav-like family member 1	DEG_SPOP_SBC_1	293:297	VLTSS	SPOP	0.8617	More...
Q9Y5T5	Ubiquitin carboxyl-terminal hydrolase 16	DEG_SPOP_SBC_1	548:552	VLTSS	SPOP	0.9998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons