DegronMD

Uniprot ID: Q92879

Source protein: CUGBP Elav-like family member 1

Source gene: CELF1

Class: DEG_SPOP_SBC_1

Location: 293:297

E3 ligase: SPOP

DEGRON score: 0.8617

ASA_SCORE: 35.64

COIL: 0.7642

CONS_SCORE: 0.3247

DSS_SCORE: 0.5093

HELIX: 0.1252

FCONS_SCORE: 0.9527

RIG_SCORE: 0.6057

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A294S	TCGA-78-8640	LUAD	TCGA	VLTSS	DEG_SPOP_SBC_1	0.7588
p.Q288R	TCGA-DI-A1BU	UCEC	TCGA	VLTSS	DEG_SPOP_SBC_1	0.1944
p.S288G	DO9708	COAD	ICGC	VLTSS	DEG_SPOP_SBC_1	0.1944
p.S299L	DO50175	LGG	ICGC	VLTSS	DEG_SPOP_SBC_1	0.2778
p.S298R	DO228985	LICA	ICGC	VLTSS	DEG_SPOP_SBC_1	0.3056
p.P297H	DO229022	LICA	ICGC	VLTSS	DEG_SPOP_SBC_1	0.7694
p.P289L	DO40900	UCEC	ICGC	VLTSS	DEG_SPOP_SBC_1	0.2222
p.L287I	DO41235	UCEC	ICGC	VLTSS	DEG_SPOP_SBC_1	0.1667
p.A283V	DO43971	UCEC	ICGC	VLTSS	DEG_SPOP_SBC_1	0.0556
p.S297P	ACH-000999	Colon/Colorectal Cancer	CCLE	VLTSS	DEG_SPOP_SBC_1	0.6752
p.S297P	SNU-1040	large_intestine	COSMIC	VLTSS	DEG_SPOP_SBC_1	0.6752
p.S293P	SNU-1040	large_intestine	COSMIC	VLTSS	DEG_SPOP_SBC_1	0.6752
p.S296P	SNU-1040	large_intestine	COSMIC	VLTSS	DEG_SPOP_SBC_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95600	Krueppel-like factor 8	DEG_SPOP_SBC_1	144:148	VLTSS	SPOP	0.9812	More...
Q5QGS0	Neurite extension and migration factor	DEG_SPOP_SBC_1	862:866	VLTSS	SPOP	0.9973	More...
Q5T7N3	KN motif and ankyrin repeat domain-containing protein 4	DEG_SPOP_SBC_1	486:490	VLTSS	SPOP	0.7879	More...
Q8N2C7	Protein unc-80 homolog	DEG_SPOP_SBC_1	3151:3155	VLTSS	SPOP	0.5821	More...
Q8NCF5	NFATC2-interacting protein	DEG_SPOP_SBC_1	334:338	VLTSS	SPOP	0.9389	More...
Q8TD26	Chromodomain-helicase-DNA-binding protein 6	DEG_SPOP_SBC_1	2129:2133	VLTSS	SPOP	0.9858	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4778:4782	VLTSS	SPOP	0.5936	More...
Q92879	CUGBP Elav-like family member 1	DEG_SPOP_SBC_1	293:297	VLTSS	SPOP	0.8617	More...
Q9Y5T5	Ubiquitin carboxyl-terminal hydrolase 16	DEG_SPOP_SBC_1	548:552	VLTSS	SPOP	0.9998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons