DegronMD

Uniprot ID: Q5T7N3

Source protein: KN motif and ankyrin repeat domain-containing protein 4

Source gene: KANK4

Class: DEG_SPOP_SBC_1

Location: 486:490

E3 ligase: SPOP

DEGRON score: 0.7879

ASA_SCORE: 77.52

COIL: 0.6822

CONS_SCORE: 0.2713

DSS_SCORE: 0.5192

HELIX: 0.1094

FCONS_SCORE: 0.7838

RIG_SCORE: 0.7047

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E484K	TCGA-05-4422	LUAD	TCGA	VLTSS	DEG_SPOP_SBC_1	0.2778
p.E484K	TCGA-19-5956	GBM	TCGA	VLTSS	DEG_SPOP_SBC_1	0.2778
p.E484K	DO13863	GBM	ICGC	VLTSS	DEG_SPOP_SBC_1	0.2778
p.E484K	DO25907	LUAD	ICGC	VLTSS	DEG_SPOP_SBC_1	0.2778
p.S489F	TCGA-DK-AA6U	BLCA	TCGA	VLTSS	DEG_SPOP_SBC_1	0.7982
p.S489F	DO219008	BLCA	ICGC	VLTSS	DEG_SPOP_SBC_1	0.7982
p.S490F	TCGA-FS-A1ZA	SKCM	TCGA	VLTSS	DEG_SPOP_SBC_1	0.7982
p.S490F	DO37551	SKCM	ICGC	VLTSS	DEG_SPOP_SBC_1	0.7982
p.S493I	TCGA-IB-7651	PAAD	TCGA	VLTSS	DEG_SPOP_SBC_1	0.25
p.S493I	DO46657	PAAD	ICGC	VLTSS	DEG_SPOP_SBC_1	0.25
p.S489Y	DO47240	RECA	ICGC	VLTSS	DEG_SPOP_SBC_1	0.712
p.Q481E	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VLTSS	DEG_SPOP_SBC_1	0.1944
p.Q481E	H513	pleura	COSMIC	VLTSS	DEG_SPOP_SBC_1	0.1944
p.H492Y	SIDM01560	Rhabdomyosarcoma	GDSC	VLTSS	DEG_SPOP_SBC_1	0.2778
p.H492Y	ACH-000133	Unknown	CCLE	VLTSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95600	Krueppel-like factor 8	DEG_SPOP_SBC_1	144:148	VLTSS	SPOP	0.9812	More...
Q5QGS0	Neurite extension and migration factor	DEG_SPOP_SBC_1	862:866	VLTSS	SPOP	0.9973	More...
Q5T7N3	KN motif and ankyrin repeat domain-containing protein 4	DEG_SPOP_SBC_1	486:490	VLTSS	SPOP	0.7879	More...
Q8N2C7	Protein unc-80 homolog	DEG_SPOP_SBC_1	3151:3155	VLTSS	SPOP	0.5821	More...
Q8NCF5	NFATC2-interacting protein	DEG_SPOP_SBC_1	334:338	VLTSS	SPOP	0.9389	More...
Q8TD26	Chromodomain-helicase-DNA-binding protein 6	DEG_SPOP_SBC_1	2129:2133	VLTSS	SPOP	0.9858	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4778:4782	VLTSS	SPOP	0.5936	More...
Q92879	CUGBP Elav-like family member 1	DEG_SPOP_SBC_1	293:297	VLTSS	SPOP	0.8617	More...
Q9Y5T5	Ubiquitin carboxyl-terminal hydrolase 16	DEG_SPOP_SBC_1	548:552	VLTSS	SPOP	0.9998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons