DegronMD

Uniprot ID: Q8TD26

Source protein: Chromodomain-helicase-DNA-binding protein 6

Source gene: CHD6

Class: DEG_SPOP_SBC_1

Location: 2129:2133

E3 ligase: SPOP

DEGRON score: 0.9858

ASA_SCORE: 68.76

COIL: 0.7984

CONS_SCORE: 0.3317

DSS_SCORE: 0.5608

HELIX: 0.0574

FCONS_SCORE: 0.9689

RIG_SCORE: 0.6997

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2143S	TCGA-EE-A20C	SKCM	TCGA	VLTSS	DEG_SPOP_SBC_1	0.0556
p.P2143S	DO222775	MELA	ICGC	VLTSS	DEG_SPOP_SBC_1	0.0556
p.P2143S	DO47665	SKCM	ICGC	VLTSS	DEG_SPOP_SBC_1	0.0556
p.R2137Q	DO228998	LICA	ICGC	VLTSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95600	Krueppel-like factor 8	DEG_SPOP_SBC_1	144:148	VLTSS	SPOP	0.9812	More...
Q5QGS0	Neurite extension and migration factor	DEG_SPOP_SBC_1	862:866	VLTSS	SPOP	0.9973	More...
Q5T7N3	KN motif and ankyrin repeat domain-containing protein 4	DEG_SPOP_SBC_1	486:490	VLTSS	SPOP	0.7879	More...
Q8N2C7	Protein unc-80 homolog	DEG_SPOP_SBC_1	3151:3155	VLTSS	SPOP	0.5821	More...
Q8NCF5	NFATC2-interacting protein	DEG_SPOP_SBC_1	334:338	VLTSS	SPOP	0.9389	More...
Q8TD26	Chromodomain-helicase-DNA-binding protein 6	DEG_SPOP_SBC_1	2129:2133	VLTSS	SPOP	0.9858	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4778:4782	VLTSS	SPOP	0.5936	More...
Q92879	CUGBP Elav-like family member 1	DEG_SPOP_SBC_1	293:297	VLTSS	SPOP	0.8617	More...
Q9Y5T5	Ubiquitin carboxyl-terminal hydrolase 16	DEG_SPOP_SBC_1	548:552	VLTSS	SPOP	0.9998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons