DegronMD

Uniprot ID: Q9Y5T5

Source protein: Ubiquitin carboxyl-terminal hydrolase 16

Source gene: USP16

Class: DEG_SPOP_SBC_1

Location: 548:552

E3 ligase: SPOP

DEGRON score: 0.9998

ASA_SCORE: 73.64

COIL: 0.7042

CONS_SCORE: 0.3715

DSS_SCORE: 0.4776

HELIX: 0.158

FCONS_SCORE: 0.9925

RIG_SCORE: 0.7839

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P553L	TCGA-D3-A3C7	SKCM	TCGA	VLTSS	DEG_SPOP_SBC_1	0.3056
p.N558S	TCGA-D7-A6EY	STAD	TCGA	VLTSS	DEG_SPOP_SBC_1	0.1667
p.T550S	ACH-001853	Bile Duct Cancer	CCLE	VLTSS	DEG_SPOP_SBC_1	0.7116

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95600	Krueppel-like factor 8	DEG_SPOP_SBC_1	144:148	VLTSS	SPOP	0.9812	More...
Q5QGS0	Neurite extension and migration factor	DEG_SPOP_SBC_1	862:866	VLTSS	SPOP	0.9973	More...
Q5T7N3	KN motif and ankyrin repeat domain-containing protein 4	DEG_SPOP_SBC_1	486:490	VLTSS	SPOP	0.7879	More...
Q8N2C7	Protein unc-80 homolog	DEG_SPOP_SBC_1	3151:3155	VLTSS	SPOP	0.5821	More...
Q8NCF5	NFATC2-interacting protein	DEG_SPOP_SBC_1	334:338	VLTSS	SPOP	0.9389	More...
Q8TD26	Chromodomain-helicase-DNA-binding protein 6	DEG_SPOP_SBC_1	2129:2133	VLTSS	SPOP	0.9858	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4778:4782	VLTSS	SPOP	0.5936	More...
Q92879	CUGBP Elav-like family member 1	DEG_SPOP_SBC_1	293:297	VLTSS	SPOP	0.8617	More...
Q9Y5T5	Ubiquitin carboxyl-terminal hydrolase 16	DEG_SPOP_SBC_1	548:552	VLTSS	SPOP	0.9998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons