DegronMD - Q92879(CELF1)

FUNCTION: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (PubMed:28431233). {ECO:0000250, ECO:0000269|PubMed:10536163, ECO:0000269|PubMed:11124939, ECO:0000269|PubMed:11158314, ECO:0000269|PubMed:12649496, ECO:0000269|PubMed:12799066, ECO:0000269|PubMed:14726956, ECO:0000269|PubMed:16601207, ECO:0000269|PubMed:16946708, ECO:0000269|PubMed:28431233}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A294S	TCGA-78-8640	LUAD	TCGA	VLTSS	DEG_SPOP_SBC_1	293:297	Mutation altering degron motif	0.7588
p.A309V	TCGA-AP-A056	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	301:305	Mutation rewiring degron network	0.2222
p.Q288R	TCGA-DI-A1BU	UCEC	TCGA	VLTSS	DEG_SPOP_SBC_1	293:297	Mutation rewiring degron network	0.1944
p.S288G	DO9708	COAD	ICGC	VLTSS	DEG_SPOP_SBC_1	293:297	Mutation rewiring degron network	0.1944
p.S299L	DO50175	LGG	ICGC	VLTSS	DEG_SPOP_SBC_1	293:297	Mutation rewiring degron network	0.2778
p.S299L	DO50175	LGG	ICGC	PSSSS	DEG_SPOP_SBC_1	301:305	Mutation rewiring degron network	0.2778
p.S298R	DO228985	LICA	ICGC	VLTSS	DEG_SPOP_SBC_1	293:297	Mutation rewiring degron network	0.3056
p.S298R	DO228985	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	301:305	Mutation rewiring degron network	0.25
p.P297H	DO229022	LICA	ICGC	VLTSS	DEG_SPOP_SBC_1	293:297	Mutation altering degron motif	0.7694
p.L314I	DO229031	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	301:305	Mutation rewiring degron network	0.0833
p.G312R	DO222727	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	301:305	Mutation rewiring degron network	0.1389
p.G312R	DO38028	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	301:305	Mutation rewiring degron network	0.1389
p.P289L	DO40900	UCEC	ICGC	VLTSS	DEG_SPOP_SBC_1	293:297	Mutation rewiring degron network	0.2222
p.L287I	DO41235	UCEC	ICGC	VLTSS	DEG_SPOP_SBC_1	293:297	Mutation rewiring degron network	0.1667
p.A283V	DO43971	UCEC	ICGC	VLTSS	DEG_SPOP_SBC_1	293:297	Mutation rewiring degron network	0.0556
p.A301V	SIDM01619	Endometrial Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	301:305	Mutation altering degron motif	0.6936
p.S297P	ACH-000999	Colon/Colorectal Cancer	CCLE	VLTSS	DEG_SPOP_SBC_1	293:297	Mutation altering degron motif	0.6752
p.S297P	SNU-1040	large intestine	COSMIC	VLTSS	DEG_SPOP_SBC_1	293:297	Mutation altering degron motif	0.6752
p.S293P	SNU-1040	large intestine	COSMIC	VLTSS	DEG_SPOP_SBC_1	293:297	Mutation altering degron motif	0.6752
p.S296P	SNU-1040	large intestine	COSMIC	VLTSS	DEG_SPOP_SBC_1	293:297	Mutation altering degron motif	0.6752

Kaplan plot for CELF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CELF1

UniProt ID: Q92879

Entrez ID: 10658

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CELF1 in