DegronMD

Uniprot ID: Q8NCF5

Source protein: NFATC2-interacting protein

Source gene: NFATC2IP

Class: DEG_SPOP_SBC_1

Location: 334:338

E3 ligase: SPOP

DEGRON score: 0.9389

ASA_SCORE: 54.84

COIL: 0.5568

CONS_SCORE: 0.4809

DSS_SCORE: 0.2817

HELIX: 0.0594

FCONS_SCORE: 0.8479

RIG_SCORE: 0.7987

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D328H	TCGA-69-7978	LUAD	TCGA	VLTSS	DEG_SPOP_SBC_1	0.1667
p.T344M	TCGA-BR-4292	STAD	TCGA	VLTSS	DEG_SPOP_SBC_1	0.1667
p.V334A	TCGA-BR-8372	STAD	TCGA	VLTSS	DEG_SPOP_SBC_1	0.5825
p.A341V	SIDM01245	T-Lymphoblastic Leukemia	GDSC	VLTSS	DEG_SPOP_SBC_1	0.25
p.A341V	SIDM01079	Melanoma	GDSC	VLTSS	DEG_SPOP_SBC_1	0.25
p.A341V	SIDM00991	T-Lymphoblastic Leukemia	GDSC	VLTSS	DEG_SPOP_SBC_1	0.25
p.S338F	SIDM00296	Small Cell Lung Carcinoma	GDSC	VLTSS	DEG_SPOP_SBC_1	0.9093
p.S338F	ACH-002051	Lung Cancer	CCLE	VLTSS	DEG_SPOP_SBC_1	0.9093
p.S338F	LU-134-A	lung	COSMIC	VLTSS	DEG_SPOP_SBC_1	0.9093
p.D331E	SIDM00619	Thyroid Gland Carcinoma	GDSC	VLTSS	DEG_SPOP_SBC_1	0.25
p.D331E	KMH-2	thyroid	COSMIC	VLTSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95600	Krueppel-like factor 8	DEG_SPOP_SBC_1	144:148	VLTSS	SPOP	0.9812	More...
Q5QGS0	Neurite extension and migration factor	DEG_SPOP_SBC_1	862:866	VLTSS	SPOP	0.9973	More...
Q5T7N3	KN motif and ankyrin repeat domain-containing protein 4	DEG_SPOP_SBC_1	486:490	VLTSS	SPOP	0.7879	More...
Q8N2C7	Protein unc-80 homolog	DEG_SPOP_SBC_1	3151:3155	VLTSS	SPOP	0.5821	More...
Q8NCF5	NFATC2-interacting protein	DEG_SPOP_SBC_1	334:338	VLTSS	SPOP	0.9389	More...
Q8TD26	Chromodomain-helicase-DNA-binding protein 6	DEG_SPOP_SBC_1	2129:2133	VLTSS	SPOP	0.9858	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4778:4782	VLTSS	SPOP	0.5936	More...
Q92879	CUGBP Elav-like family member 1	DEG_SPOP_SBC_1	293:297	VLTSS	SPOP	0.8617	More...
Q9Y5T5	Ubiquitin carboxyl-terminal hydrolase 16	DEG_SPOP_SBC_1	548:552	VLTSS	SPOP	0.9998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons