DegronMD - Q5QGS0(NEXMIF)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q872L	SIDM00541	Colorectal Carcinoma	GDSC	VLTSS	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.1667
p.Q872L	HT55	large intestine	COSMIC	VLTSS	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.1667
p.P367L	SIDM00190	Melanoma	GDSC	SSDFSQFKVPDV	DEG_COP1_1	358:369	Mutation altering degron motif	0.7582
p.P367L	CP66-MEL	skin	COSMIC	SSDFSQFKVPDV	DEG_COP1_1	358:369	Mutation altering degron motif	0.7582
p.E375K	SIDM01154	T-Lymphoblastic Leukemia	GDSC	SSDFSQFKVPDV	DEG_COP1_1	358:369	Mutation rewiring degron network	0.1667
p.E375K	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	SSDFSQFKVPDV	DEG_COP1_1	358:369	Mutation rewiring degron network	0.1667
p.L863F	SIDM00217	Colorectal Carcinoma	GDSC	VLTSS	DEG_SPOP_SBC_1	862:866	Mutation altering degron motif	0.587
p.L863F	SNU-1040	large intestine	COSMIC	VLTSS	DEG_SPOP_SBC_1	862:866	Mutation altering degron motif	0.587
p.K1090N	SIDM00864	Cervical Carcinoma	GDSC	PPDTPSLS	DEG_SCF_FBW7_1	1073:1080	Mutation blocking ubiquitination signal	0.5
p.K1090N	DoTc2-4510	cervix	COSMIC	PPDTPSLS	DEG_SCF_FBW7_1	1073:1080	Mutation blocking ubiquitination signal	0.5
p.L1079I	SIDM00479	Esophageal Carcinoma	GDSC	PPDTPSLS	DEG_SCF_FBW7_1	1073:1080	Mutation altering degron motif	0.6063
p.L1079I	OE19	oesophagus	COSMIC	PPDTPSLS	DEG_SCF_FBW7_1	1073:1080	Mutation altering degron motif	0.6063
p.D27Y	SIDM01254	Burkitt's Lymphoma	GDSC	VKEND	DEG_APCC_KENBOX_2	23:27	Mutation altering degron motif	0.6214
p.S1377Y	KARPAS-299	haematopoietic and lymphoid tissue	COSMIC	LAGTPQES	DEG_SCF_FBW7_1	1370:1377	Mutation altering degron motif	0.712

Kaplan plot for NEXMIF in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NEXMIF

UniProt ID: Q5QGS0

Entrez ID: 340533

Protein name: Neurite extension and migration factor (XLMR protein related to neurite extension) (XPN)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NEXMIF in