DegronMD

Uniprot ID: Q5QGS0

Source protein: Neurite extension and migration factor

Source gene: NEXMIF

Class: DEG_COP1_1

Location: 358:369

E3 ligase: COP1

DEGRON score: 0.9741

ASA_SCORE: 78.5833

COIL: 0.7068

CONS_SCORE: 0.5803

DSS_SCORE: 0.3872

HELIX: 0.2008

FCONS_SCORE: 1.1661

RIG_SCORE: 0.7628

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P367L	SIDM00190	Melanoma	GDSC	SSDFSQFKVPDV	DEG_COP1_1	0.7582
p.P367L	CP66-MEL	skin	COSMIC	SSDFSQFKVPDV	DEG_COP1_1	0.7582
p.E375K	SIDM01154	T-Lymphoblastic Leukemia	GDSC	SSDFSQFKVPDV	DEG_COP1_1	0.1667
p.E375K	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	SSDFSQFKVPDV	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5QGS0	Neurite extension and migration factor	DEG_COP1_1	358:369	SSDFSQFKVPDV	COP1	0.9741	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons