DegronMD

Uniprot ID: Q5QGS0

Source protein: Neurite extension and migration factor

Source gene: NEXMIF

Class: DEG_SCF_FBW7_1

Location: 1073:1080

E3 ligase: FBXW7

DEGRON score: 0.9974

ASA_SCORE: 72.825

COIL: 0.9246

CONS_SCORE: 0.9109

DSS_SCORE: 0.6759

HELIX: 0.0395

FCONS_SCORE: 1.1922

RIG_SCORE: 0.6099

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1090N	SIDM00864	Cervical Carcinoma	GDSC	PPDTPSLS	DEG_SCF_FBW7_1	0.5
p.K1090N	DoTc2-4510	cervix	COSMIC	PPDTPSLS	DEG_SCF_FBW7_1	0.5
p.L1079I	SIDM00479	Esophageal Carcinoma	GDSC	PPDTPSLS	DEG_SCF_FBW7_1	0.6063
p.L1079I	OE19	oesophagus	COSMIC	PPDTPSLS	DEG_SCF_FBW7_1	0.6063

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5QGS0	Neurite extension and migration factor	DEG_SCF_FBW7_1	1073:1080	PPDTPSLS	FBXW7	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons