DegronMD - Q8NCF5(NFATC2IP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D328H	TCGA-69-7978	LUAD	TCGA	VLTSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1667
p.T344M	TCGA-BR-4292	STAD	TCGA	VLTSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1667
p.V334A	TCGA-BR-8372	STAD	TCGA	VLTSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.5825
p.E57D	TCGA-F5-6814	READ	TCGA	SRGTLDVVS	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.0556
p.E57D	DO36556	READ	ICGC	SRGTLDVVS	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.0556
p.G41D	TCGA-WS-AB45	COAD	TCGA	SRGTLDVVS	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.6087
p.G41D	DO51734	COAD	ICGC	SRGTLDVVS	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.6087
p.E31Q	DO51893	BLCA	ICGC	SRGTLDVVS	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1111
p.R33W	DO229016	COCA	ICGC	SRGTLDVVS	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1667
p.R33W	DO229047	LICA	ICGC	SRGTLDVVS	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1667
p.D49H	DO24920	LUAD	ICGC	SRGTLDVVS	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.2778
p.T32A	DO26772	LUSC	ICGC	SRGTLDVVS	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1389
p.S47F	DO222615	MELA	ICGC	SRGTLDVVS	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.6871
p.V55A	DO47873	STAD	ICGC	SRGTLDVVS	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1111
p.A341V	SIDM01245	T-Lymphoblastic Leukemia	GDSC	VLTSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.25
p.A341V	SIDM01079	Melanoma	GDSC	VLTSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.25
p.A341V	SIDM00991	T-Lymphoblastic Leukemia	GDSC	VLTSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.25
p.S338F	SIDM00296	Small Cell Lung Carcinoma	GDSC	VLTSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.9093
p.S338F	ACH-002051	Lung Cancer	CCLE	VLTSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.9093
p.S338F	LU-134-A	lung	COSMIC	VLTSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.9093
p.D331E	SIDM00619	Thyroid Gland Carcinoma	GDSC	VLTSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.25
p.D331E	KMH-2	thyroid	COSMIC	VLTSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.25
p.T52I	ACH-000617	Ovarian Cancer	CCLE	SRGTLDVVS	DEG_APCC_DBOX_1	39:47	Mutation blocking phosphorylation signal	0.6389
p.E31K	SK-MEL-5	skin	COSMIC	SRGTLDVVS	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1111
p.S46F	LU-134-A	lung	COSMIC	SRGTLDVVS	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.7982
p.D52E	KMH-2	thyroid	COSMIC	SRGTLDVVS	DEG_APCC_DBOX_1	39:47	Mutation blocking phosphorylation signal	0.6389
p.D39E	KMH-2	thyroid	COSMIC	SRGTLDVVS	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.6758

Kaplan plot for NFATC2IP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NFATC2IP

UniProt ID: Q8NCF5

Entrez ID: 84901

Protein name: NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NFATC2IP in