DegronMD

Uniprot ID: Q8NCF5

Source protein: NFATC2-interacting protein

Source gene: NFATC2IP

Class: DEG_APCC_DBOX_1

Location: 39:47

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9943

ASA_SCORE: 77.7556

COIL: 0.7019

CONS_SCORE: 0.358

DSS_SCORE: 0.5485

HELIX: 0.0652

FCONS_SCORE: 0.9632

RIG_SCORE: 0.7215

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E57D	TCGA-F5-6814	READ	TCGA	SRGTLDVVS	DEG_APCC_DBOX_1	0.0556
p.E57D	DO36556	READ	ICGC	SRGTLDVVS	DEG_APCC_DBOX_1	0.0556
p.G41D	TCGA-WS-AB45	COAD	TCGA	SRGTLDVVS	DEG_APCC_DBOX_1	0.6087
p.G41D	DO51734	COAD	ICGC	SRGTLDVVS	DEG_APCC_DBOX_1	0.6087
p.E31Q	DO51893	BLCA	ICGC	SRGTLDVVS	DEG_APCC_DBOX_1	0.1111
p.R33W	DO229016	COCA	ICGC	SRGTLDVVS	DEG_APCC_DBOX_1	0.1667
p.R33W	DO229047	LICA	ICGC	SRGTLDVVS	DEG_APCC_DBOX_1	0.1667
p.D49H	DO24920	LUAD	ICGC	SRGTLDVVS	DEG_APCC_DBOX_1	0.2778
p.T32A	DO26772	LUSC	ICGC	SRGTLDVVS	DEG_APCC_DBOX_1	0.1389
p.S47F	DO222615	MELA	ICGC	SRGTLDVVS	DEG_APCC_DBOX_1	0.6871
p.V55A	DO47873	STAD	ICGC	SRGTLDVVS	DEG_APCC_DBOX_1	0.1111
p.T52I	ACH-000617	Ovarian Cancer	CCLE	SRGTLDVVS	DEG_APCC_DBOX_1	0.6389
p.E31K	SK-MEL-5	skin	COSMIC	SRGTLDVVS	DEG_APCC_DBOX_1	0.1111
p.S46F	LU-134-A	lung	COSMIC	SRGTLDVVS	DEG_APCC_DBOX_1	0.7982
p.D52E	KMH-2	thyroid	COSMIC	SRGTLDVVS	DEG_APCC_DBOX_1	0.6389
p.D39E	KMH-2	thyroid	COSMIC	SRGTLDVVS	DEG_APCC_DBOX_1	0.6758

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NCF5	NFATC2-interacting protein	DEG_APCC_DBOX_1	39:47	SRGTLDVVS	APC,CDC20,FZR1	0.9943	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons