DegronMD - Q5T7N3(KANK4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E484K	TCGA-05-4422	LUAD	TCGA	ERVLLPQLS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.1667
p.E484K	TCGA-05-4422	LUAD	TCGA	VLTSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.2778
p.E484K	TCGA-19-5956	GBM	TCGA	ERVLLPQLS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.1667
p.E484K	TCGA-19-5956	GBM	TCGA	VLTSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.2778
p.E484K	DO13863	GBM	ICGC	ERVLLPQLS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.1667
p.E484K	DO13863	GBM	ICGC	VLTSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.2778
p.E484K	DO25907	LUAD	ICGC	ERVLLPQLS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.1667
p.E484K	DO25907	LUAD	ICGC	VLTSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.2778
p.P625T	TCGA-85-A511	LUSC	TCGA	PASSS	DEG_SPOP_SBC_1	625:629	Mutation altering degron motif	0.7031
p.P625T	DO45509	LUSC	ICGC	PASSS	DEG_SPOP_SBC_1	625:629	Mutation altering degron motif	0.7031
p.Q466E	TCGA-86-8671	LUAD	TCGA	ERVLLPQLS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.2222
p.Q466E	DO24080	LUAD	ICGC	ERVLLPQLS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.2222
p.A469T	TCGA-BG-A220	UCEC	TCGA	ERVLLPQLS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.3056
p.A469T	DO41784	UCEC	ICGC	ERVLLPQLS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.3056
p.V633M	TCGA-BH-A0HK	BRCA	TCGA	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.2222
p.V633M	DO5717	BRCA	ICGC	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.2222
p.H461Y	TCGA-BR-8687	STAD	TCGA	ERVLLPQLS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.0833
p.H461Y	DO47801	STAD	ICGC	ERVLLPQLS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.0833
p.S489F	TCGA-DK-AA6U	BLCA	TCGA	VLTSS	DEG_SPOP_SBC_1	486:490	Mutation altering degron motif	0.7982
p.S489F	DO219008	BLCA	ICGC	VLTSS	DEG_SPOP_SBC_1	486:490	Mutation altering degron motif	0.7982
p.S628F	TCGA-EE-A2GC	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	625:629	Mutation altering degron motif	0.7982
p.S628F	DO37839	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	625:629	Mutation altering degron motif	0.7982
p.S490F	TCGA-FS-A1ZA	SKCM	TCGA	VLTSS	DEG_SPOP_SBC_1	486:490	Mutation altering degron motif	0.7982
p.S490F	DO37551	SKCM	ICGC	VLTSS	DEG_SPOP_SBC_1	486:490	Mutation altering degron motif	0.7982
p.P631L	TCGA-G4-6628	COAD	TCGA	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.2778
p.P631L	DO10132	COAD	ICGC	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.2778
p.P631L	SIDM00875	Breast Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.2778
p.P631L	ACH-000624	Breast Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.2778
p.P631L	HCC1806	breast	COSMIC	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.2778
p.S493I	TCGA-IB-7651	PAAD	TCGA	VLTSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.25
p.S493I	DO46657	PAAD	ICGC	VLTSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.25
p.Q466H	TCGA-XF-A8HE	BLCA	TCGA	ERVLLPQLS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.2222
p.Q466H	DO49797	BLCA	ICGC	ERVLLPQLS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.2222
p.A469V	DO224768	BRCA	ICGC	ERVLLPQLS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.3056
p.P621H	DO10486	COAD	ICGC	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.2222
p.Q463K	DO229019	LICA	ICGC	ERVLLPQLS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.1389
p.P631Q	DO229035	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.2778
p.R471S	DO229045	LICA	ICGC	ERVLLPQLS	DEG_APCC_DBOX_1	470:478	Mutation altering degron motif	0.7427
p.A616T	DO232835	NACA	ICGC	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.0833
p.S489Y	DO47240	RECA	ICGC	VLTSS	DEG_SPOP_SBC_1	486:490	Mutation altering degron motif	0.712
p.S630P	DO218876	SKCA	ICGC	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.3056
p.R471C	SIDM00777	Colorectal Carcinoma	GDSC	ERVLLPQLS	DEG_APCC_DBOX_1	470:478	Mutation altering degron motif	0.8301
p.R471C	NCI-H508	large intestine	COSMIC	ERVLLPQLS	DEG_APCC_DBOX_1	470:478	Mutation altering degron motif	0.8301
p.S630F	SIDM00602	Gastric Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.3056
p.S630F	SIDM01511	Gastric Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.3056
p.S630F	ACH-000746	Gastric Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.3056
p.S630F	ACH-000919	Gastric Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.3056
p.S630F	IM-95	stomach	COSMIC	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.3056
p.K462E	SIDM00447	B-Lymphoblastic Leukemia	GDSC	ERVLLPQLS	DEG_APCC_DBOX_1	470:478	Mutation substituting flanking lysine	0.2222
p.K462E	REH	haematopoietic and lymphoid tissue	COSMIC	ERVLLPQLS	DEG_APCC_DBOX_1	470:478	Mutation substituting flanking lysine	0.2222
p.Q481E	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	ERVLLPQLS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.25
p.Q481E	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VLTSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.1944
p.Q481E	H513	pleura	COSMIC	ERVLLPQLS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.25
p.Q481E	H513	pleura	COSMIC	VLTSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.1944
p.A618V	SIDM00245	Small Cell Lung Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.1389
p.A618V	ACH-001131	Skin Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.1389
p.A618V	ACH-001958	lung	CCLE	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.1389
p.A618V	MS-1	lung	COSMIC	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.1389
p.S630C	SIDM00271	Gastric Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.3056
p.S630C	MKN1	stomach	COSMIC	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.3056
p.K462T	SIDM00850	Gastric Carcinoma	GDSC	ERVLLPQLS	DEG_APCC_DBOX_1	470:478	Mutation substituting flanking lysine	0.2222
p.K462T	ACH-000880	Gastric Cancer	CCLE	ERVLLPQLS	DEG_APCC_DBOX_1	470:478	Mutation substituting flanking lysine	0.2222
p.K462T	AGS	stomach	COSMIC	ERVLLPQLS	DEG_APCC_DBOX_1	470:478	Mutation substituting flanking lysine	0.2222
p.P624L	SIDM00056	Thyroid Gland Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.3056
p.P624L	ACH-002148	Thyroid Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.3056
p.P624L	K5	thyroid	COSMIC	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.3056
p.E623D	SIDM01611	Endometrial Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.2778
p.E623D	ACH-000996	Endometrial/Uterine Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.2778
p.H492Y	SIDM01560	Rhabdomyosarcoma	GDSC	VLTSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.2778
p.H492Y	ACH-000133	Unknown	CCLE	VLTSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.2778
p.Q466R	ACH-000387	Leukemia	CCLE	ERVLLPQLS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KANK4

UniProt ID: Q5T7N3

Entrez ID: 163782

Protein name: KN motif and ankyrin repeat domain-containing protein 4 (Ankyrin repeat domain-containing protein 38)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KANK4 in