DegronMD

Uniprot ID: Q5T7N3

Source protein: KN motif and ankyrin repeat domain-containing protein 4

Source gene: KANK4

Class: DEG_APCC_DBOX_1

Location: 470:478

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9814

ASA_SCORE: 96.2556

COIL: 0.7137

CONS_SCORE: 0.3238

DSS_SCORE: 0.5795

HELIX: 0.1604

FCONS_SCORE: 1.2365

RIG_SCORE: 0.7559

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E484K	TCGA-05-4422	LUAD	TCGA	ERVLLPQLS	DEG_APCC_DBOX_1	0.1667
p.E484K	TCGA-19-5956	GBM	TCGA	ERVLLPQLS	DEG_APCC_DBOX_1	0.1667
p.E484K	DO13863	GBM	ICGC	ERVLLPQLS	DEG_APCC_DBOX_1	0.1667
p.E484K	DO25907	LUAD	ICGC	ERVLLPQLS	DEG_APCC_DBOX_1	0.1667
p.Q466E	TCGA-86-8671	LUAD	TCGA	ERVLLPQLS	DEG_APCC_DBOX_1	0.2222
p.Q466E	DO24080	LUAD	ICGC	ERVLLPQLS	DEG_APCC_DBOX_1	0.2222
p.A469T	TCGA-BG-A220	UCEC	TCGA	ERVLLPQLS	DEG_APCC_DBOX_1	0.3056
p.A469T	DO41784	UCEC	ICGC	ERVLLPQLS	DEG_APCC_DBOX_1	0.3056
p.H461Y	TCGA-BR-8687	STAD	TCGA	ERVLLPQLS	DEG_APCC_DBOX_1	0.0833
p.H461Y	DO47801	STAD	ICGC	ERVLLPQLS	DEG_APCC_DBOX_1	0.0833
p.Q466H	TCGA-XF-A8HE	BLCA	TCGA	ERVLLPQLS	DEG_APCC_DBOX_1	0.2222
p.Q466H	DO49797	BLCA	ICGC	ERVLLPQLS	DEG_APCC_DBOX_1	0.2222
p.A469V	DO224768	BRCA	ICGC	ERVLLPQLS	DEG_APCC_DBOX_1	0.3056
p.Q463K	DO229019	LICA	ICGC	ERVLLPQLS	DEG_APCC_DBOX_1	0.1389
p.R471S	DO229045	LICA	ICGC	ERVLLPQLS	DEG_APCC_DBOX_1	0.7427
p.R471C	SIDM00777	Colorectal Carcinoma	GDSC	ERVLLPQLS	DEG_APCC_DBOX_1	0.8301
p.R471C	NCI-H508	large_intestine	COSMIC	ERVLLPQLS	DEG_APCC_DBOX_1	0.8301
p.K462E	SIDM00447	B-Lymphoblastic Leukemia	GDSC	ERVLLPQLS	DEG_APCC_DBOX_1	0.2222
p.K462E	REH	haematopoietic_and_lymphoid_tissue	COSMIC	ERVLLPQLS	DEG_APCC_DBOX_1	0.2222
p.Q481E	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	ERVLLPQLS	DEG_APCC_DBOX_1	0.25
p.Q481E	H513	pleura	COSMIC	ERVLLPQLS	DEG_APCC_DBOX_1	0.25
p.K462T	SIDM00850	Gastric Carcinoma	GDSC	ERVLLPQLS	DEG_APCC_DBOX_1	0.2222
p.K462T	ACH-000880	Gastric Cancer	CCLE	ERVLLPQLS	DEG_APCC_DBOX_1	0.2222
p.K462T	AGS	stomach	COSMIC	ERVLLPQLS	DEG_APCC_DBOX_1	0.2222
p.Q466R	ACH-000387	Leukemia	CCLE	ERVLLPQLS	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T7N3	KN motif and ankyrin repeat domain-containing protein 4	DEG_APCC_DBOX_1	470:478	ERVLLPQLS	APC,CDC20,FZR1	0.9814	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERVLLPQLS

Degron related mutations and impact score

Drug responses associated with KANK4 mutations

All proteins holding degron of ERVLLPQLS